Prealbumina, precalicreína e protrombina na forma hepatesplênica da esquistossomose: catabolismo aumentado de proteínas da coagulação?

Manoukian, N; Borges, Durval Rosa

doi:10.1590/s0036-46651984000500001

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…Clinically, no important hemorrhagic tendencies were ob- 1). The reduction in prothrombin time, also described by other authors [23], is related either to reduced hepatic synthesis or to increased consumption [24,25]. Hypersplenism, defined by the number of platelets below 100,000/ram 3, associated or not with a leukocyte count below 4,000/ram 3, was observed in 89.4% of the patients.…”

Section: Clinical Laboratory and Ultrasonographic Featuresmentioning

confidence: 55%

Portal hypertension in mansonic schistosomiasis

1991

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Mansonic schistosomiasis is an endemic disease in Brazil, with an estimated 10-12 million people infested. Among its clinical manifestations, the hepatosplenic form causes portal hypertension which, in turn, brings about severe digestive hemorrhage, the most serious complication of the disease. Normally, the patients are young, and have hepatosplenomegaly, hypersplenism without clinical manifestations, and slightly reduced hepatic function. The angiographic findings are characteristic, differing from those of hepatic cirrhosis. In Brazil, the definitive treatment for gastrointestinal hemorrhage is surgery, which should be done under elective conditions whenever possible. During a short period of time, known as the "risk period" (the time between the hemorrhagic episode and the surgery), propranolol has been used to prevent further bleeding. Surgical treatment is indicated only after the first episode, and never on a prophylactic basis. In 1977, a prospective, randomized trial was begun in order to assess the delayed results of the 3 surgical operations most widely used in this country. The study was interrupted after 94 patients had been operated on due to the high incidence of encephalopathy in the group who underwent classical splenorenal shunt. After a follow-up of at least 60 months and, at most, 130 months, the results showed that classical splenorenal shunt caused encephalopathy in 39.3% of the cases and distal splenorenal shunt in 14.8%. None of those submitted to esophagogastric devascularization with splenectomy developed encephalopathy. The 3 procedures showed similar rates of hemorrhagic recurrence.

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Section: Clinical Laboratory and Ultrasonographic Featuresmentioning

confidence: 55%

Portal hypertension in mansonic schistosomiasis

1991

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“…Clinical data suggest the participation of kinins in schistosomiasis pathophysiology. PPK and HMWK concentrations were lower in hepatosplenic schistosomiasis patients, when compared with the control group [ 173 , 174 ]. A therapeutic approach employing a short human kininogen insertion into S. japonicum glutathione S-transferases, ameliorated their biological activity, and inhibited human umbilical vein endothelial cell proliferation [ 175 ].…”

Section: Kinins and Their Implication In Protozoan And Parasite Inmentioning

confidence: 99%

Kinins and Their Receptors in Infectious Diseases

2020

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Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. Literature data provides compelling evidence about the participation of kinins in infections caused by diverse agents, including viral, bacterial, fungal, protozoan, and helminth-related ills. It is tempting to propose that modulation of kinin actions and production might be an adjuvant strategy for management of infection-related complications.

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