Asociación entre plomo en sangre y parámetros sociodemográficos en población infantil

Rojas, M. Guadalupe; Espinosa, Carlos; Seijas, David

doi:10.1590/s0034-89102003000400016

Cited by 14 publications

(7 citation statements)

References 12 publications

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“…Initially, lead poisoning presents subclinically, but it tends to worsen through compromising different organs and systems, such as the kidneys, liver, central nervous system (CNS), peripheral nervous system (PNS) and the neuromuscular, hematopoietic, endocrine, reproductive and cardiovascular systems (Smith et al;De Capitani, 2009). Rojas et al (2003) reported that although lead exposure is declining in developing countries, chronic contamination due to low-level exposure continues to be a significant problem for children's health.…”

Section: Introductionmentioning

confidence: 99%

Absorption Levels and Morphological Features of Fetal Organs in Wistar Rats Treated with Lead Acetate

et al. 2012

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SUMMARY:Lead is one of the heavy metals most used in industry. Poisoning due to long-term lead exposure is known as saturnism, and is an occupational illness that has been known for many years. Lead is highly toxic and can compromise the structural and functional patterns of organs and systems. The aim of this study was to examine the lungs and kidneys of fetuses from female Wistar rats exposed to lead acetate. In this study, the lungs and kidneys of 20 fetuses from female rats that had previously been treated with lead acetate were dissected, fixed, embedded in paraffin and stained with hematoxylin and eosin. Macroscopic changes to the shape, color and consistency of organs from fetuses treated with this heavy metal were observed, in comparison with organs from control fetuses. Microscopic lesions characterized by vascular sclerosis, cell atrophy or hyperplasia, progressive interstitial fibrosis, inclusion bodies containing lead acetate and glomerular sclerosis were found in the kidneys. The lesions found in the lungs consisted of destructuring of the parenchyma, impregnation with lead acetate, formation of fibrosis, extravasation of vascular fluids, reduction of the alveolar spaces and formation of alveolar edema. These changes were correlated with the level of lead acetate absorption, as determined using atomic spectrophotometry.

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Section: Introductionmentioning

confidence: 99%

Absorption Levels and Morphological Features of Fetal Organs in Wistar Rats Treated with Lead Acetate

et al. 2012

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“…About 99% of all children affected by exposure to lead live in low- and middle-income countries (Suk et al 2003). Children living in poverty are most likely to be exposed to lead (Rojas et al 2003; Seijas and Squillante 2008). …”

Section: Specific Environmental Health Threats To Children In Latin Amentioning

confidence: 99%

Children’s Health in Latin America: The Influence of Environmental Exposures

Laborde

Tomasina

Bianchi

et al. 2015

Environ Health Perspect

115

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BackgroundChronic diseases are increasing among children in Latin America.Objective and MethodsTo examine environmental risk factors for chronic disease in Latin American children and to develop a strategic initiative for control of these exposures, the World Health Organization (WHO) including the Pan American Health Organization (PAHO), the Collegium Ramazzini, and Latin American scientists reviewed regional and relevant global data.ResultsIndustrial development and urbanization are proceeding rapidly in Latin America, and environmental pollution has become widespread. Environmental threats to children’s health include traditional hazards such as indoor air pollution and drinking-water contamination; the newer hazards of urban air pollution; toxic chemicals such as lead, asbestos, mercury, arsenic, and pesticides; hazardous and electronic waste; and climate change. The mix of traditional and modern hazards varies greatly across and within countries reflecting industrialization, urbanization, and socioeconomic forces.ConclusionsTo control environmental threats to children’s health in Latin America, WHO, including PAHO, will focus on the most highly prevalent and serious hazards—indoor and outdoor air pollution, water pollution, and toxic chemicals. Strategies for controlling these hazards include developing tracking data on regional trends in children’s environmental health (CEH), building a network of Collaborating Centres, promoting biomedical research in CEH, building regional capacity, supporting development of evidence-based prevention policies, studying the economic costs of chronic diseases in children, and developing platforms for dialogue with relevant stakeholders.CitationLaborde A, Tomasina F, Bianchi F, Bruné MN, Buka I, Comba P, Corra L, Cori L, Duffert CM, Harari R, Iavarone I, McDiarmid MA, Gray KA, Sly PD, Soares A, Suk WA, Landrigan PJ. 2015. Children’s health in Latin America: the influence of environmental exposures. Environ Health Perspect 123:201–209; http://dx.doi.org/10.1289/ehp.1408292

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“…A exposição a esse agente neurotóxico durante os períodos pré, peri e pós-natal (até dois anos), acarreta sérias conseqüências que perduram da infância à adolescência, uma vez que a concentração de chumbo em tecidos cerebrais permanece elevada, por um período consideravelmente maior que nos tecidos sangüíneos, mesmo depois de breve período de exposição (6)(7) .…”

Section: Introductionunclassified

A exposição ao chumbo como fator de risco para alterações no desenvolvimento da linguagem

Jorge

Vitto

Lamônica

et al. 2008

Rev. soc. bras. fonoaudiol.

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OBJETIVO: Verificar a ocorrência de alterações no desenvolvimento, em particular, o desenvolvimento da linguagem, em crianças com histórico de exposição ao metal chumbo, e a existência ou não de correlação entre índice de contaminação e desenvolvimento de linguagem. MÉTODOS: Cinqüenta e oito crianças entre 12 e 36 meses foram submetidas à triagem fonoaudiológica; destas, 15 compareceram para avaliação específica por meio da Escala de Desenvolvimento Comportamental de Gesell e Amatruda por terem falhado na triagem. A correlação entre índice de chumbo e o grau de defasagem na linguagem foi verificada. RESULTADOS: Seis crianças apresentaram defasagem na área da linguagem da Escala, sendo que, uma delas apresentou defasagem em todos os campos. CONCLUSÃO: Não foi encontrada correlação negativa significante entre a concentração de chumbo e o grau de defasagem no desenvolvimento de linguagem dos indivíduos participantes, entretanto, o estudo sugere que a contaminação pelo chumbo tornou-se fator de risco para alterações no desenvolvimento da linguagem destas crianças. Dessa forma, mais estudos são necessários para verificar o grau de prejuízo que este metal pode ocasionar às pessoas, principalmente quando estão em desenvolvimento.

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Asociación entre plomo en sangre y parámetros sociodemográficos en población infantil

Cited by 14 publications

References 12 publications

Absorption Levels and Morphological Features of Fetal Organs in Wistar Rats Treated with Lead Acetate

Absorption Levels and Morphological Features of Fetal Organs in Wistar Rats Treated with Lead Acetate

Children’s Health in Latin America: The Influence of Environmental Exposures

A exposição ao chumbo como fator de risco para alterações no desenvolvimento da linguagem

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