Características histopatológicas necessárias para a pesquisa de bacilos álcool-ácido resistentes no eritema nodoso

Pires, Mário Cézar; Calux, Marli de Jesus Ferreira; Valente, Neusa Yuriko Sakai

doi:10.1590/s0034-89101996000600007

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The infiltration of neutrophils is specific to lepromatous ENL while it is lymphocyte infiltration in erythema nodosum of other causes 9. Chaudhary reported a case of lepromatous ENL with a very high leucocyte count in the peripheral blood and he named it as a myeloid leukemoid reaction 10.…”

Section: Discussionmentioning

confidence: 99%

Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: A case report

Rathinam¹,

Khazaei²,

Job³

2008

Indian J Ophthalmol

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Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae, clinically present either as tuberculoid, borderline or lepromatous type. Erythema nodosum leprosum (ENL) is an acute humoral response in the chronic course of lepromatous leprosy. Although very severe ENL reactions are known in systemic leprosy, such severity is rare in ocular tissues. A leprosy uveitis patient suffered from a severe form of post- therapeutic ENL reaction which resulted in perforation of the globe at the site of preexisting subconjunctival leproma. Painful blind eye was enucleated. Histopathological study revealed infiltration of numerous polymorphs and macrophages packed with acid-fast bacilli in the conjunctiva, cornea, ciliary body, ora serrata and sclera. A profuse influx of neutrophils on a background of macrophages packed with M. leprae confirmed the ocular ENL reaction. This case is reported to alert the ophthalmologists to a rare ocular complication of ENL.

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Section: Discussionmentioning

confidence: 99%

Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: A case report

Rathinam¹,

Khazaei²,

Job³

2008

Indian J Ophthalmol

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Ocular leprosy

Grzybowski¹,

Nita²,

Virmond³

2015

Clinics in Dermatology

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Ocular involvement in leprosy is estimated to be 70-75%, about 10-50% of leprosy patients suffer from severe ocular symptoms, and blindness occurs in about 5% of patients. The disease leads to many ophthalmologic symptoms and signs in the range of the eyeball itself, as well as of the bulb adnexa, ie, eyebrows, eyelids with eyelashes, and lacrimal drainage system. Especially dangerous are complications of lagophthalmos and corneal hypoanesthesia, neurotrophic or infectious keratitis, and iridocyclitis and cataract formation, which may lead to significant decrease of visual acuity or even blindness. Multidrug treatment rapidly interrupts transmission of Mycobacterium leprae by infectious patients, but even after being completed, it does not guarantee the withholding of ocular complications.

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Ocular erythema nodosum leprosum: An immunohistochemical study

Rathinam

Parikh

Rao³

2020

Indian J Ophthalmol

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Episcleritis, scleritis, and anterior uveitis are common clinical manifestations of ocular leprosy. Erythema nodosum leprosum (ENL) is an acute, exaggerated systemic immunological reaction that complicates the course of this chronic indolent disease. We present an ocular immunohistochemical study of severe form of ENL involving even the ciliary body and choroid resulting in the perforation of the globe on the initiation of anti leprosy therapy. We used CD-3, CD-68, S-100, and CD-20 for immunohistochemistry. It revealed plenty of CD-3-positive T-cells and CD-68-positive macrophages and a few S-100 and CD-20-positive cells. The inflammatory exudates stained positive for IgG and IgM. The diagnosis was ocular ENL.

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Características histopatológicas necessárias para a pesquisa de bacilos álcool-ácido resistentes no eritema nodoso

Cited by 3 publications

References 3 publications

Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: A case report

Histopathological study of ocular erythema nodosum leprosum and post-therapeutic scleral perforation: A case report

Ocular leprosy

Ocular erythema nodosum leprosum: An immunohistochemical study

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