Relação entre a patogenicidade do Schistoma mansoni em camundongos e a susceptibilidade do molusco vetor: II. Número de ovos nas fezes e número e tamanho dos granulomas nas vísceras

Zanotti-Magalhães, Eliana Maria; Magalhães, Luiz Augusto; Carvalho, José Ferreira de

doi:10.1590/s0034-89101993000600003

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…Geographically isolated strains of S. mansoni present significant differences in pathogenicity, which is attributed to greater impairment of organs due to the greater extent and wider distribution of S. mansoni eggs [16], the number of eggs produced by the parasite [7, 17], and the degree of susceptibility of the snail vector [1, 16, 18, 19]. According to Chieffi and Waldman [1], the rarity of hepatosplenic forms in autochthonous cases in São Paulo State (Brazil) may be due to the low rates of snail infection by S. mansoni , which reflects the lower susceptibility of infection of B. tenagophila compared to B. glabrata and B. straminea .…”

Section: Discussionmentioning

confidence: 99%

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Euzébio

Zuim

Linhares³

et al. 2012

Interdisciplinary Perspectives on Infectious Diseases

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The pathogenesis of three different Schistosoma mansoni strains from the Brazilian states of Minas Gerais (BH strain) and São Paulo (SJ and SD strains) was evaluated in experimentally infected mice. Observations of the most severe clinical cases among local patients treated (SD strain) in the city of Campinas (São Paulo, Brazil) formed the basis of this study. Mice were used as definitive hosts and were infected with cercariae from Biomphalaria tenagophila (SJ and SD strains) and Biomphalaria glabrata (BH strains). The parameters analyzed were as follows: number of S. mansoni eggs in mice feces; number of granulomas per tissue area in liver, spleen, lungs, pancreas, and ascending colon; measurements of hepatic and intestinal granulomas; number of adult worms; and measurements of trematode eggs. The comparison among the three strains indicated that the SD strain, isolated in Campinas, presented a higher worm recovery relative to the number of penetrating cercariae. In addition, when compared to the SJ and BH strains, the SD strain demonstrated similar pathogenicity to the BH strain, with a greater quantity of granulomas in the viscera, as well as larger granulomas and eggs. Furthermore, a greater quantity of trematode eggs was also shed in the feces.

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Section: Discussionmentioning

confidence: 99%

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Euzébio

Zuim

Linhares³

et al. 2012

Interdisciplinary Perspectives on Infectious Diseases

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“…Foram medidas as reações granulomatosas que continham ovos de S. mansoni, tomando-se os diâmetros maior e menor através da utilização da ocular micrométrica 21 .…”

Section: Methodsunclassified

Schistosoma mansoni: estudo da patogenia da linhagem Santa Rosa (Campinas, SP, Brasil) em camundongos

Yoshioka

Zanotti-Magalhães

Magalhães

et al. 2002

Rev. Soc. Bras. Med. Trop.

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The present paper reports the comparison between a newly isolated strain of S. mansoni in the city of Campinas (SP, Brazil) named SR, with the strains BH (Belo Horizonte, MG, Brazil) and SJ (São José dos Campos, SP, Brazil). The study was done using mice experimentally infected with 70 cercariae from sympatric snails: B. glabrata for the BH strain and B. tenagophila for the SJ and SR strains. The data obtained revealed that the new strain is less pathogenic than the other two, since it yielded fewer worms and shed eggs, a lower number of granulomas and a smaller granuloma size in the liver and intestine.

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“…hospedadores intermediarios a la infección por S. mansoni ha sido relacionada con la acción patógena del trematodo. En efecto, se ha señalado para el sistema S. mansoni -B. tenagophila (S.J., Brasil) que a mayor susceptibilidad, hubo mayor número de huevos en las heces, de granulomas hepáticos 17 , mayor mortalidad de los ratones infectados y menor peso corporal y de las visceras 18 .…”

Section: Discusion L a S U S C E P T I B I L I D A D D E L O S M O L unclassified

Compatibilidad entre nueve cepas de Biomphalaria glabrata de áreas endémicas y no endémicas y una cepa de Schistosoma mansoni venezolanas

Pino

Matinella²,

1999

Rev. Soc. Bras. Med. Trop.

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Nine lots of 32 B. glabrata snails (5-7mm in diameter) from the following strains from the endemic area: Cagua, Valencia Lake (Puerta Negra Sector), Ingenio Bolívar (Aragua State), Mariara, Caserío El 25 and Güigüe (Carabobo state), and from the non-endemic area: Anzoátegui (Lara state), Chabasquén (Portuguesa state) and Caripe (Monagas state) were experimentally infected (5 miracidiums/snail) with C5 Schistosoma mansoni strain. The intramolluscal prepatent period oscillated between 23 and 25 days for the nine strains. The duration of intramolluscal infection varied a lot, from 20 days in the case of the Chabasquén strain to 93 days for the Güigüe strain. The average cercariae production in the 3rd day of emission varied from X = 74.4 for the Mariara strain to 591.7 in the case of the Chabasquén strain. Significant statistical differences were found in relation to the total number of emitted cercariae in the 3rd day (H = 97.4; P < 0.05), with significant statistical differences detected among most of the 36 strain combinations, except for the following: Mariara/Ingenio Bolívar, Cagua/Cas. El 25, Valencia Lake/Güigüe and Güigüe/Caripe. The strains of Valencia Lake (88.8%), Cagua (85.2), Chabasquén (82.6%) and Caripe (82.6%) showed the highest rates of self-cure, whereas the Güigüe strain showed the lowest: 21.4%.

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Relação entre a patogenicidade do Schistoma mansoni em camundongos e a susceptibilidade do molusco vetor: II. Número de ovos nas fezes e número e tamanho dos granulomas nas vísceras

Abstract: Relação entre a patogenicidade do

Cited by 8 publications

References 24 publications

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Experimental Evaluation of the Pathogenicity of Different Strains ofSchistosoma mansoni

Schistosoma mansoni: estudo da patogenia da linhagem Santa Rosa (Campinas, SP, Brasil) em camundongos

Compatibilidad entre nueve cepas de Biomphalaria glabrata de áreas endémicas y no endémicas y una cepa de Schistosoma mansoni venezolanas

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