A case-control study on the association of hepatitis B virus infection and hepatocellular carcinoma in Northeast Brazil

Cotrim, Helma Pinchemel; Mota, Eduardo; Leite, Livia; Silva, Luciana; Lyra, Luiz Guilherme Costa

doi:10.1590/s0034-89101992000500001

Cited by 1 publication

(3 citation statements)

References 11 publications

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“…90,91 While HBV is the most frequent cause of HCC in many countries of Asia and South America, both HBV and HCV are found at similar frequencies, and eventually HCV at a higher frequency than HBV, among HCC patients in Europe, North America, and Japan. 89,[92][93][94][95][96] The cumulative appearance rate of HCC is higher for HCV-infected cirrhotic patients than for HBV-infected ones. 89,97 It is not known at the present if HDV infection is associated with the development or the worsening of HCC in HBV-infected patients.…”

Section: Other Parenterally Transmitted Virusesmentioning

confidence: 99%

“…In the last few years, an increasing number of evidence has emerged, some of them controversial, establishing potential interactions between some HBV and HCV proteins and host-cell proteins implicated in cell growth control (Table 1). [92][93][94][95][96][97][98][99][100][101][102][103][104][105] HBV GENETIC VARIABILITY AND PROGRESSION TO HCC Epidemiologic differences in terms of HCC evolution in HBV-infected patients have been also observed. Some HBV genotypes might be implicated in a more aggressive infection than others.…”

Section: Other Parenterally Transmitted Virusesmentioning

confidence: 99%

“…Putative Mechanisms of Cellular Transformation by HBV and HCV[92][93][94][95][96][97][98][99][100][101][102][103][104][105] …”

mentioning

confidence: 99%

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Genotypic Variability of Hepatitis Viruses Associated With Chronic Infection and the Development of Hepatocellular Carcinoma

Pujol¹,

Devesa²

2005

Journal of Clinical Gastroenterology

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At least five hepatitis viruses are known to date. Infection by enterically transmitted viruses (HAV and HEV) is generally benign compared with the disease caused by parenterally transmitted viruses (HBV, HCV, and HDV). Chronic infection by HBV is common and may evolve to cirrhosis and hepatocellular carcinoma (HCC). Eight HBV genotypes (A-H) have been described, with the South American genotype F being the most divergent. Seven clades of HDV have been described; among them, the South American genotype III is associated to a high frequency of fulminant hepatitis. HCV infection leads to a high rate of chronicity and HCC. From the six HCV genotypes, infection with genotype 1 might have the worst prognostic. Chronic infection by HCV and HBV is the major risk factor for HCC, which occurs, in the majority of the cases, as a consequence of cirrhosis. However, there is growing evidence that some HBV and HCV proteins might contribute to the generation of HCC. Some HBV and HCV variants and specific mutations within the viral genomes might be more frequently associated with the evolution to HCC. Although more studies are needed, emerging evidence indicates that it might be important to address the genetic variability of these viruses and their contribution to the development of HCC.

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