Estudo experimental comparativo entre o butil-2-cianoacrilato, a mistura gelatina-resorcina-formaldeído e sutura na estabilização de enxertos de cartilagem em coelhos

Abstract

Cart ilage grafting is an interesting option for rinoplasties refinements. Aim: to compare butyl-2-cyanocrylate, compound gelatin-resorcin-formaldeyide (GRF) and suture control to determine the efficacy of these tissue glue preparations in securing grafted cartilage. Study Design: Experimental. Methods: Fifteen male adult New Zealand rabbits were submitted to a surgical procedure to harvest 6 auricular cartilage grafts from each animal. 2 of these grafts in each animal were glued together with butyl-2-cyanocrylate, 2 with compound gelatin-resorcin-formaldehyde and 2 sewn together with nylon suture. These sandwich grafts were then glued or sewn to the periosteum of the calvaria. After 2, 6 and 12 weeks, groups of 5 animals were sacrificed and histological analysis for inflammation was performed. Cartilage graft migration, adhesion and deformities of the grafts were also evaluated. Results: there was less migration of the cartilages glued with GRF than with cyanoacrylate and suture. There was no statistical difference between the 3 materials of graft stabilization in relation to the inflammatory reaction in all evaluated periods. There wasn't detachment neither deformity in the cartilage sandwiches sewed with suture. The majority of detachment and deformed cartilages were found among those glued with cyanoacrylate. The number of deformed cartilages was directly related to the number of detached cartilages. The data were statistically significant (p< 0.05). Conclusion: the compound gelatin-resorcin-formaldehyde revealed to be a stabilization material for cartilage grafts in rabbits better than butyl-2-cyanoacrylate. The compound gelatin-resorcin-formaldeyide was also better than the suture when comparing it's fixation to the periosteum.

Use of cyanoacrylate-based surgical adhesives associated to the macroporous tape in skin synthesis in rats

“…In an experimental study, Costa et al 24 . comparing the use of butyl-2-cyanoacrylate, suture and gelatin-resorcinol-formaldehyde (GRF) blend in the stabilization of cartilage grafts in rabbits, found a more significant inflammatory process in the three groups in the first two weeks decreasing up to 12 weeks.…”

Experimental study of the use of auricular cartilage with and without Gelfoam® on the nasal dorsum of rabbits✩✩Please cite this article as: Silva BSR, Dolci JEL. Experimental study of the use of auricular cartilage with and without Gelfoam® on the nasal dorsum of rabbits. Braz J Otorhinolaryngol. 2014;80:111–9.,✩✩✩✩Study conducted at Hospital Santa Casa de São Paulo, São Paulo, SP, Brazil.

“…Some authors have reported the use of several different grafts for correction of saddle nose from distant regions such as fascia lata, 27 temporoparietal bone, 24 inferior turbinate, 23 subcutaneous muscular aponeurotic system (SMAS), 19 without taking into consideration the numerous alloplastic grafts, as described by Sheen, 17 Costa et al, 26 and Tostes et al 28…”

“…Doner et al, 10 determined that the best material for graft fixation would be cyanoacrylate instead of sutures, whereas Costa et al 26 compared graft stabilization with butyl-2-cyanoacrylate, GRF and sutures. However, in the present study, it was decided not to fix the grafts, similarly to other studies by Peynegre et al, 14 Gurlek et al, 22 and Souza.…”

“…In a study performed by Costa et al, 26 15 rabbits were assessed to compare the use of butyl-2-cyanoacrylate, gelatin-resorcinol-formaldehyde (GRF), and suture in the stabilization of cartilage grafts in rabbits, from whose ears six cartilage grafts were resected, fixed in the periosteum of the skull, and united two-by-two with suture, GRF, and cyanoacrylate. GRF was shown to be a superior method of stabilization of cartilage grafts in rabbits when compared to butyl-2-cyanoacrylate in all cases, and superior to suture in bone-cartilage fixation.…”

Comparison of Polyurethane With Cyanoacrylate in Hemostasis of Vascular Injury in Guinea Pigs

“…After recovery, the animals were returned to their cages. They were given pain medication (5 mg/kg tramadol hydrochloride, intramuscularly) during the first 3 postoperative (PO) days [ 14 ] .…”