Potencial cognitivo P300 em indivíduos com diabetes mellitus

Abstract

Di abetes Mellitus may lead to alterations in the eyes, kidneys, cranial nerves, peripheral nerves, ears etc. The cognitive function also seems to be compromised in subjects presented with Diabetes Mellitus, since the cortical and subcortical structures responsible for this function are hindered in some insulin-dependent patients. The cognitive potential P300 has been used as an objective procedure to assess cerebral cognitive functions. Aim: To analyze the sensitivity of P300 cognitive potential for the detection of alterations on the auditory cortex secondary to Diabetes Mellitus. Study design: transversal cohort. Material and Method: Sixteen diabetic subjects of both genders aged 7 to 71 years, and seventeen non-diabetic individuals at the same age range participated in this study. The evaluation procedures were pure tone audiometry (PTA) and P300 cognitive potential. Glycemia of the group presented with Diabetes was assessed prior to applying P300. Results: No statistically significant difference was shown for PTA results. A statically significant difference was observed between groups when analyzing the latency of P300 component measured in Fz. There was a correlation between glycemia and latency and amplitude of P300. Conclusion: The investigation of the cognitive potential of P300 is an important procedure for prevention and early diagnosis of neurological changes in individuals presented with Diabetes Mellitus.

Redução da mobilidade funcional e da capacidade cognitiva no diabetes melito tipo 2

“…Por outro lado, pacientes dependentes demoram mais de 20 segundos. Pacientes que demoram de 10 a 20 segundos possuem certo grau de limitação, porém ainda são considerados independentes (19,20).…”

Mobilidade funcional e função executiva em idosos diabéticos e não diabéticos

“…However, ageing associated to a disease such as diabetes mellitus progressively leads the individual to further damage 2,3 . Diabetes mellitus is a syndrome of multiple etiologies, resulting from the lack of insulin and/or the inability of this hormone to properly exert its effects, which may lead to the development of associated diseases and complications such as retinopathy, nephropathy, peripheral neuropathy, loss of joint mobility and muscle strength 4 . Moreover, cognitive function also seems to become altered in individuals with diabetes mellitus 5 .…”

Possíveis implicações audiológicas do diabetes melito: uma revisão de literatura

“…Louise Ziani de David (1) , Marcele Machado Finamor (2) , Ceres Buss (3) (1) CEFAC -Saúde e Educação, São Paulo, SP, Brasil. (2) Universidade Federal do Rio Grande do Sul -UFRGS, Porto Alegre, RS, Brasil.…”

“…The metabolic control of type II diabetes is usually achieved with diet, physical exercises and/or concomitant use of oral hypoglycemic agents, insulin may be used in the treatment 1 . This study aims to analyze the relationship between diabetes mellitus, type I and II, and possible hearing disorders.…”

“…The results of this study showed that the decrease in blood glucose level in diabetic individual leads to increased latency and decreased amplitude of the P300 component, suggesting a dysfunction in the central auditory system. Considering that the nervous tissue is glucose-dependent, i.e., dependent on a stable level of glucose in ideal situations, extended periods of hypoglycemia episodes can lead to significant individual neurological alterations 1 …”