Pleomorphic adenoma is a mixed, benign tumor with more common occurrence in the salivary glands, mainly in the parotid and submandibular gland, being less frequent in the intraoral region, when it occurs, it has a preference for the palate, lip and buccal mucosa. The objective of this work is to present two clinical cases of Pleomorphic Adenoma with different and atypical locations, and to choose the best form of treatment for each specific case, as well as to describe the clinical stages of management with the patient from surgery to the postoperative period. The present research took place in an HEI with two patients diagnosed with pleomorphic adenoma, one in the hard palate and the other in the upper lip. The diagnosis was made through biopsy and histopathological examination. In view of the above, we can observe that the Pleomorphic Adenoma is a pathology that deserves to be highlighted, given that it has particular characteristics, and the knowledge of the Dental Surgeon about this pathology is extremely important, in order to carry out an early diagnosis. These peculiar characteristics will help in the most specific conduct for each region, always aiming to reduce the chances of malignancy and recurrence.