Detecção precoce de ototoxicidade usando emissões otoacústicas produtivas de distorção

Vallejo, Juan C.; Silva, Mercedes N.; Oliveira, José Antônio Apparecido de; Carneiro, João José; Rocha, Luiz S. O.; Figueiredo, J F C; Chiosi, Maria F. V.

doi:10.1590/s0034-72992001000600014

Cited by 24 publications

(29 citation statements)

References 19 publications

(25 reference statements)

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“…The same was observed in another study (19) , which reported constant improvement in DPOAE responses, rather than deterioration, and attributed this improvement to cochlear lesion or dysfunction in the area close to the response, which favors the capture conditions of the "response sound" through these injured regions, causing them to be captured with greater ease by the device probe, or, even, by an irritation of the CCE before the lesion, as occurs in the cells of the vestibular system. This was also reported by other researchers (20) , who found an increase in the signal/noise ratio at 1 and 2 kHz, after a dose of 120 mg/m 2 of cisplatin; however, there was a decrease after a dose of 240 mg/m 2 .…”

Section: Discussionsupporting

confidence: 89%

“…This indicates the importance of high frequencies (6 and 8 kHz), which were not tested in our study due to the limitation of the equipment used. There is a consensus among researchers (5,7,19) that the auditory alterations caused by the use of ototoxic drugs initially involve high frequencies; hence, it is important to use equipment that can attain these frequencies.…”

Section: Discussionmentioning

confidence: 99%

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Caracterização audiológica de crianças em tratamento oncológico

Caldas

Brito

Caldas

et al. 2015

Audiol., Commun. Res.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Caracterização audiológica de crianças em tratamento oncológico

Caldas

Brito

Caldas

et al. 2015

Audiol., Commun. Res.

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“…The use of new toxicological analysis showed that the prevalence of fetus exposition to drug abuse in developing countries is higher than the estimated [29]. This evidence was found in a study conducted at Porto Alegre-Brazil, where the pre-gestational exposition to cocaine was 4.6% [30].…”

Section: Antibiotic Therapy N (%)mentioning

confidence: 91%

Prevalence of newborn bacterial meningitis and sepsis during the pregnancy period for public health care system participants in Salvador, Bahia, Brazil

Silva¹,

Cavalheiro²,

Queirós³

et al. 2007

Braz J Infect Dis

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Bacterial meningitis is still a major public health threat inside developing countries. In Brazil, the Department of Public Health estimates that the prevalence of bacterial meningitis is 22 cases per 100,000 persons. During the neonatal period, the bacterial meningitis develops special characteristics that can result in hearing problems and movement loss due to neurological and psychological damages. This study had the aim to analyze the prevalence of bacterial meningitis and sepsis in newborns during the pregnancy period for those using the public health care system in Salvador-Bahia. One of the goal was to describe the risk factors of bacterial meningitis and sepsis in newborns. A second goal was to identify, based on newborn health records, the difficulties to predict issues with the hearing, neurological and psychological problems. This study has a cross-sectional design. The newborns that were included in this study had bacterial meningitis or sepsis within 0-28 days of life. They were admitted in the maternity wards between June-December 2005 at the newborn intensive unit care. We analyzed 72 reports of newborns and only 11 (17%) were bacterial meningitis or sepsis newborn cases. These cases were associated to high intake of ototoxic drugs that can cause oto and nephrotoxicity, and cause serious sequels on the child development. Nervous system infection is one of the 2 major problems in clinical practice, especially during the first month after birth. During this first month, the nervous system infection develops special characteristics, which are different from regular symptoms and it requires treatment due to the increased risk to develop complications. It is strongly recommended to monitor ototoxic drugs use to prevent effects on the hearing system. Key-Words: Newborn meningitis, sepsis, prevalence, prediction, complications.The neonatal meningitis is an illness characterized as a result of infection and inflammation of the meninges and it typically happens between birth and the first 28 days of life [1].The bacterial infection is more common during the first month after birth compared to other stages of newborns. It has an incidence that varies from 0.22 to 2.66/1,000 newborns in different countries and it tends to be more common in developing countries [2].During the neonatal period, the illness has special characteristics. The etiology, the clinical symptoms and the mortality appear to be different from the observed in older children [3].The mortality varies based on the treatment, with survival rates of 17% to 29% and with complications rate of 15% to 68%. Among the predictive factors for determining the diagnosis of this condition are the premature birth, newborn weight, type of bacteria, predisposition for the microbial germ, the length of the treatment and complications [4].Although there have been medical advances of medicines and preventive medicine, the incidence of newborn bacterial meningitis for the last 30 years has been barely affected. This minor change in the incidence can be linked po...

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“…Nephrotoxicity, ototoxicity and neuromuscular blockade are the most important toxic effects of aminoglycosides (Oliveira, 2006;Vallejo et al, 2001). The adverse effects of clindamycin consist mainly of gastrointestinal disorders that can manifest as severe diarrhea and pseudomembranous colitis (Katzung, 2005).…”

Section: Metabolitesmentioning

confidence: 99%

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

Figueredo¹,

Lucena²,

Tintino³

et al. 2013

Pharmaceutical Biology

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Context: The combination of antibiotics with natural products has demonstrated promising synergistic effects in several therapeutic studies. Objective: The aim of this study was to determine the effect of a combination of an ethanol extract of Myracrodruon urundeuva Fr. All. (Anacardiaceae) (aroeira plant) and its essential oil with six antimicrobial drugs against multiresistant strains of Staphylococcus aureus and Escherichia coli from clinical isolates. Materials and methods: After identification of the chemical components by GC-MS, the antibacterial activity of the natural products and antibiotics was assessed by determining the minimal inhibitory concentration (MIC) using the microdilution method and concentrations ranging 8-512 mg/mL and 0.0012-2.5 mg/mL, respectively. Assays were performed to test for a possible synergistic action between the plant products and the antimicrobials, using the extract and the oil at a sub-inhibitory concentration (128 mg/mL) and antibiotic at concentrations varying between 8 and 512 mg/mL. Results: The GC-MS analysis identified the main compound as d-carene (80.41%). The MIC of the natural products was 41024 mg/mL, except against S. aureus ATCC25923. Only the combinations of the natural products with gentamicin, amikacin and clindamycin were effective against S. aureus 358, enhancing the antibiotic activity by reducing the MIC. Conclusions: The extract from aroeira showed a higher antibacterial activity and the oil was more effective in potentiating the activity of conventional antibiotics.

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Detecção precoce de ototoxicidade usando emissões otoacústicas produtivas de distorção

Abstract: Rev Bras Otorrinolaringol. V.67, n.6, 845-51, nov./dez. 2001 Palavras-chave: emissões otoacústicas, ototoxicidade, detecção precoce.

Cited by 24 publications

References 19 publications

Caracterização audiológica de crianças em tratamento oncológico

Caracterização audiológica de crianças em tratamento oncológico

Prevalence of newborn bacterial meningitis and sepsis during the pregnancy period for public health care system participants in Salvador, Bahia, Brazil

Chemical composition and evaluation of modulatory of the antibiotic activity from extract and essential oil of Myracrodruon urundeuva

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