AIDS e a escola: proposta interdisciplinar e institucional de prevenção

Carvalho, Regina de Oliveira

doi:10.1590/s0034-71671998000200006

Cited by 2 publications

(2 citation statements)

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“…They protect oxidative damage to DNA, and protein and lipids are thought to be primarily responsible for the inhibition of cell proliferation (18). Bixin was reported to bind to protein and reduce cholesterol, triacylglycerols, and blood glucose levels (19), whereas β-carotene was reported to be effective against several types of cancers (20). Also, β-carotene was detected in the human plasma bound to low-density lipoprotein and it acted as an antioxidant (21).…”

Section: Resultsmentioning

confidence: 99%

Relative Inhibition of Lipid Peroxidation, Cyclooxygenase Enzymes, and Human Tumor Cell Proliferation by Natural Food Colors

Reddy

Alexander-Lindo

Nair

2005

J. Agric. Food Chem.

270

168

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The most abundant water soluble natural food colors are betacyanins and anthocyanins. Similarly, lycopene, bixin, beta-carotene, and chlorophyll are water insoluble colors. Pure betanin, bixin, lycopene, chlorophyll, beta-carotene, and cyanidin-3-O-glucoside were isolated from Beta vulgaris, Bixa orellana,Lycopersicum esculentum, Spinacia oleracea, Daucus carrota, and Prunus cerasus, respectively. These natural pigments, alone and in combination, were evaluated for their relative potencies against cyclooxygenase enzymes and tumor cell growth inhibition by using MCF-7 (breast), HCT-116 (colon), AGS (stomach), CNS (central nervous system), and NCI-H460 (lung) tumor cell lines. Among the colors tested, betanin, cyanidin-3-O-glucoside, lycopene, and beta-carotene inhibited lipid peroxidation. However, all pigments tested gave COX-1 and COX-2 inhibition and showed a dose-dependent growth inhibition against breast, colon, stomach, central nervous system, and lung tumor cells, respectively. The mixtures of these pigments were also evaluated for their synergistic effects and chemical interactions at various concentrations. The mixture of anthocyanin and betanin negated their efficacy in the cell growth inhibitory assay and did not enhance the COX enzyme inhibitory activity. This is the first report of a comparative evaluation and the impact on biological activities of these pigments alone and in combination.

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