Terapia lipídica com dois agentes na intoxicação por ropivacaína: estudo experimental em suínos

Bonfim, Matheus Rodrigues; Melo, Marcos De Simone; Dreyer, Elisabeth; Borsoi, Luís Fernando Affini; Oliveira, Thales Gê de; Udelsmann, Artur

doi:10.1590/s0034-70942012000500008

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…On the other hand, hypertriglyceridemia was already expected as an effect of the use of ILE, because it is a source of fatty acids. 29,62,63 Harvey et al 64 However, hypertriglyceridemia control is important because it is considered a risk factor for acute pancreatitis. 65 In the groups that did not receive ILE, no variation in cholesterol concentration was observed, whereas a significant increase was seen in groups IV_LE and LE (Table 6).…”

Section: Discussionmentioning

confidence: 99%

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Intravenous lipid emulsion treatment in rabbits with ivermectin toxicosis

Branco

Mattoso

Botelho

et al. 2021

J Vet Emergen Crit Care

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Objective: To determine the effect and safety of IV lipid emulsion in rabbits with acute ivermectin toxicosis.Design: Randomized controlled trial.Setting: University research facility.Animals: Twenty-four healthy male adult New Zealand rabbits.Interventions: Three groups of rabbits (IV, IV_RL, and IV_LE) received 80 mg/kg of ivermectin (8 mL/kg) through a nasogastric tube, and 1 group (LE) received an equivalent volume (8 mL/kg) of 0.9% sodium chloride. Group IV_RL was treated with Ringer's lactate (2 mL/kg bolus, followed by 0.25 mL/kg/min for 60 minutes), whereas groups IV_LE and LE received 20% lipid emulsion. The rabbits were submitted to clinical and neurological evaluation, and blood samples were collected for biochemical analysis.All animals were euthanized, and tissue samples were collected and processed for histopathological evaluation and ivermectin quantification.Measurements and main results: All animals exposed to ivermectin manifested clinical changes consistent with toxicosis, but the ones that received IV lipid emulsion infusion showed no significant clinical improvement. Intense increase in serum glucose and triglyceride concentrations was seen after ivermectin exposure, along with increased urea and creatinine concentrations, but the last 2 remained within the reference range.Lipid emulsion caused an intense increase in triglycerides and cholesterol concentrations. No pathological abnormalities were seen in the organs sampled. Toxicological analysis showed greater ivermectin concentration in adipose tissue and liver, followed by kidney and, finally, brain. The treatments did not change ivermectin tissue concentration.

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Section: Discussionmentioning

confidence: 99%

“…On the other hand, hypertriglyceridemia was already expected as an effect of the use of ILE, because it is a source of fatty acids 29,62,63 . Harvey et al 64 demonstrated a rapid increase in triglyceride concentration after administration of 20% ILE in rabbits intoxicated by clomipramine.…”

Section: Discussionmentioning

confidence: 99%