Hiperalgesia induzida por opioides (HIO)

Leal, Plínio da Cunha; Clivatti, Jefferson; Garcia, João Batista Santos; Sakata, Rioko Kimiko

doi:10.1590/s0034-70942010000600011

Cited by 7 publications

(1 citation statement)

References 40 publications

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“…The main mechanism of hyperalgesia induced by opioids is the activation of N-methyl-D-aspartate (NMDA) receptors [11][12][13][14] . Ketamine is a NMDA receptor antagonist, which acts by non-competitive blockage, binding itself to the intra-channel phencyclidinic site and changing the channel opening time.…”

Section: Introductionmentioning

confidence: 99%

Avaliação do efeito da cetamina associada à remifentanila na dor pós-operatória

Leal¹,

Sakata²,

Salomão³

et al. 2013

Rev. Bras. Anestesiol.

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Background and objectives: The combination of ketamine and remifentanil seems to be associated with better analgesia and duration. The aim of this study was to evaluate whether a ketamineremifentanil combination promotes improved postoperative analgesia. Methods: Prospective, randomized, double blind study of 40 patients undergoing video laparoscopic cholecystectomy. Anesthesia was performed with remifentanil, propofol, atracurium, and 50% oxygen. Group 1 (GI) patients received remifentanil (0.4 mcg.kg ) and saline solution. Morphine 0.1 mg.kg -1 was administered at the end of the procedure, and postoperative pain was treated with morphine via PCA. We evaluated the severity of postoperative pain by a numerical scale from zero to 10 during 24 hours. We registered the time to the fi rst analgesic supplementation, amount of morphine used in the fi rst 24 hours, and adverse effects. Results: There was a decrease in pain severity between extubation and other times evaluated in G1 and G2. There was no signifi cant difference in pain intensity between the groups. There was no difference between G1 (22 ± 24.9 min) and G2 (21.5 ± 28.1 min) regarding time to fi rst dose of morphine and dose supplement of morphine consumed in G1 (29 ± 18.4 mg) and G2 (25.1 ± 13.3 mg). Conclusion: The combination of ketamine (5 mcg.kg

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Section: Introductionmentioning

confidence: 99%