Caracterização anestésica da nanoemulsão não lipídica de propofol

Sudo, Roberto T.; Bonfá, Laura; Trachez, Margarete M.; Debom, Roberto; Rizzi, Marisa D. R; Zapata‐Sudo, Gisele

doi:10.1590/s0034-70942010000500004

Cited by 3 publications

(8 citation statements)

References 14 publications

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“…A study about the use of propofol microemulsion in dogs also showed lower values of mean blood pressure from the fifth minute of the experiment, which is the moment near the end of examination and awakening of the patients evaluated in the mentioned study 7 . In a study with rats 12 , lower values of mean blood pressure occurred after one-hour infusion of propofol nanoemulsion. The doses of lipid propofol and propofol nanoemulsion allowed an appropriate anesthetic plan to perform upper digestive endoscopy without cardiorespiratory alterations of clinical relevance.…”

Section: Discussionmentioning

confidence: 93%

“…The acetic acid and the lipid propofol caused 46.0 ± 2.0 and 12.5 ± 0.6 distresses in the 20 minutes following the intraperitoneal injection, respectively. Abdominal distress after the administration of propofol nanoemulsion was not observed, which indicates that the animals had less pain on injection with such solution 12 .…”

Section: Discussionmentioning

confidence: 95%

“…It is worth mentioning that there are few studies about clinical use of formulations of propofol nanoemulsion 12 .…”

Section: Discussionmentioning

confidence: 99%

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Estudo comparativo entre propofol em nanoemulsão não lipídica com solutol e em emulsão com lecitina

Rodrigues¹,

Alexandrino²,

Kanczuk³

et al. 2012

Rev. Bras. Anestesiol.

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Summary: Rodrigues TA, Alexandrino RA, Kanczuk ME, Gozzani JL, Mathias LAST -A Comparative Study of Non-Lipid Nanoemulsion of Propofol with Solutol and Propofol Emulsion with Lecithin.Background and Objectives: Some formulations have been proposed to reduce the adverse reactions due to the lipid emulsion containing soybean oil used as propofol carrier. This study for endoscopy sedation was aimed at evaluating and comparing the safety, effectiveness and adverse effects of the use of propofol nanoemulsion compared to propofol currently commercialized.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

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Estudo comparativo entre propofol em nanoemulsão não lipídica com solutol e em emulsão com lecitina

Rodrigues¹,

Alexandrino²,

Kanczuk³

et al. 2012

Rev. Bras. Anestesiol.

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“…Para a indução do estimulo nociceptivo foi administrado o ácido acético a 0,6% (0,1N) intraperitonealmente (i.p.) em cada animal, na proporção de 10mL/Kg, 20 minutos após a administração de cada tratamento (SUDO et al, 2010), conforme tabela 1. Imediatamente após a aplicação do acido acético, cada animal foi colocado em caixa plástica e iniciada a contagem do numero de contorções abdominais por um período de 20 minutos.…”

Section: Avaliação Da Atividade Antinociceptivaunclassified

Efeito antinociceptivo da própolis oriunda de duas vegetações distintas

Batista

Trindade

Batista

2015

Semin. Cienc. Biol. Saude

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ResumoThe aim of this study was to evaluate the analgesic effect of propolis, comparing solutions prepared from propolis obtained from the apiary of the Centre for Agricultural Sciences (CCA) of the Federal University of Piauí, with the extract from the Apis Flora Laboratory. Forty eight mice were divided into six groups treated with hydroethanol solution (vehicle, 20mL/Kg, p.o.), dipyrone (positive control, 50mL/Kg, p.o.), propolis solution 10% (obtained from CCA and Apis Flora, 20mL/Kg, p.o.) and propolis 20% solution (obtained from CCA and Apis Flora, 20mL/Kg, p.o.). The nociceptive stimulus was induced by intraperitoneal (i.p.) administration of 0.6% acetic acid 20 minutes after administration of each treatment. The number of writhing was performed, for a period of 20 minutes, and the inhibition percentage of the painful sensation provided by each treatment were calculated. The results showed that the control group, treated with hydroethanol solution, was significantly different from all others, and those treated with propolis solution at 10% and 20% from, both sources do not differ significantly from each other and not the positive control, showing similar analgesic effect.Palavras-chave: Dor. Própolis. Antinocicepção.

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“…6,7 Thus, taking into consideration that propofol is the intravenous anesthetic most commonly used in general anesthesia worldwide, its use still has limitations due to adverse effects, and there are few studies comparing conventional propofol with propofol nanoemulsion. We conducted a comparative evaluation between propofol formulations traditionally used (soy lecithin and nanoemulsion with solutol) in gynecological procedures.…”

Section: Introductionmentioning

confidence: 99%