Reação cutânea grave induzida por carbamazepina no tratamento da neuralgia pós-herpética: relato de caso

Garcia, João Batista Santos; Ferro, Letácio Santos Garcia; Carvalho, Anamada Barros; Rocha, Rosyane Moura da; Souza, Livia Maria Lima de

doi:10.1590/s0034-70942010000400011

Cited by 1 publication

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“…Regarding the complications reported, two of the patients studied died, as a result of sepsis and multiple organ failure (Garcia et al, 2010;Quinones et al, 2011), while one of the patients presented clinically relevant ocular complications (Das et al, 2011). The literature corroborates these results, as the most frequent complications resulting from SJS and TEN are sepsis, which can lead to death, and keratoconjunctivitis, which can lead to conjunctival retraction, scarring, and corneal lesions.…”

Section: Discussionmentioning

confidence: 80%

Risk factors for, and treatment of, Stevens-Johnson syndrome and toxic epidermal necrolysis: Evidence from the literature

Silva¹,

Novaes²,

GÃ¶ttems³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are adverse drug reactions.They occur in the form of mild and sometimes severe cutaneous eruptions, with high morbidity and mortality, requiring fast and appropriate diagnosis and treatment. The aim of this study was to describe and discuss the evidence regarding the risk factors, complications and treatment of SJS and TEN in inpatients. The present study is a literature review of case reports published between January 1981 and December 2016, in the following databases: The Virtual Health Library (Biblioteca Virtual da Saúde -BVS), MEDLINE (National Library of Medicine, USA), LILACS (Latin American and Caribbean Health Sciences Literature), and PUBMED -NCBI (National Center for Biotechnology Information). A total of thirteen case reports were selected. Most of the cases (54%) developed adverse reactions to anticonvulsant drugs. The most common were valproic acid, lamotrigine and carbamazepine. In 69% of all cases, the patients were female. The patients' age range varied from 18 to 82 years old. In two cases which correspond to 15%, the patients were either infected with HIV or were receiving chemotherapy treatment for cancer. These patients had a higher possibility for immunosuppression. In relation to the actions taken as treatment, the suspension of the drugs or the treatment of the skin lesions occurred in 85 and 54% of the cases, respectively. A total of 6 cases, corresponding to 46%, occurred in the Latin American and Caribbean region. In conclusion, the use of anticonvulsants, and female gender, are among the main risk factors identified by the study. The main therapeutic action for SJS and TEN is the suspension of the use of the drug that triggered the inflammatory process and the topical treatment of the lesions caused.

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Section: Discussionmentioning

confidence: 80%