Avaliação da influência do polimorfismo do códon 16 do receptor beta-2 adrenérgico na incidência de hipotensão arterial e uso de efedrina em grávidas submetidas à anestesia subaracnoidea

Magalhães, Edno; Gomes, Maurício Daher Andrade; Barra, Gustavo Barcelos; Govêia, Cátia Sousa; Ladeira, Luis Cláudio Araújo

doi:10.1590/s0034-70942010000300002

Rev. Bras. Anestesiol.

2010

DOI: 10.1590/s0034-70942010000300002

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Avaliação da influência do polimorfismo do códon 16 do receptor beta-2 adrenérgico na incidência de hipotensão arterial e uso de efedrina em grávidas submetidas à anestesia subaracnoidea

Edno Magalhães

Maurício Daher Andrade Gomes²,

Gustavo Barcelos Barra³

et al.

Abstract: Background and objectives:The beta-2 adrenergic receptor gene has several polymorphisms. Recent studies have demonstrated the clinical importance of the latter. The objective of the present study was to evaluate the influence of the Arg16Gli polymorphism on the incidence of arterial hypotension and ephedrine use in pregnant patients submitted to subarachnoid block for Cesarean section.

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The effect of beta‐2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery*

Daher¹,

Saito²,

Barra³

et al. 2012

Anaesthesia

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SummaryWe investigated whether genetic variations of the beta-2 adrenergic receptor (ADRB2) modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. We focused on the effects of haplotypes formed by combinations of the Arg16Gly and Gln27Glu polymorphisms. Clinical data from 143 healthy parturients were collected. Only the ArgGln haplotype appeared to influence the risk of hypotension, most probably through a recessive mode of inheritance (p = 0.027). Therefore, patients were grouped according to ArgGln homozygosity in two groups: presence of one or no copies of the haplotype (n = 120) or two copies of the haplotype (n = 23). Both groups presented similar baseline characteristics. Comparatively, patients homozygous for the ArgGln haplotype presented consistently higher blood pressure levels throughout the evaluation period (p = 0.001 for systolic arterial pressure variation from baseline). In conclusion, our results demonstrate that haplotype variations of the the ADRB2 modulate the haemodynamic response following spinal anaesthesia for caesarean delivery. The description of genetic markers that could identify parturients more susceptible to develop hypotension would have a therapeutic interest, and a more individualised approach could then be undertaken. Moreover, this information may improve our knowledge of the genetic mechanisms involved with haemodynamic regulation, contributing to investigations in different clinical scenarios, such as septic shock.

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The effect of beta‐2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery*

Daher¹,

Saito²,

Barra³

et al. 2012

Anaesthesia

View full text Add to dashboard Cite

show abstract

Genomics relevant to the neuroanaesthesiologist

Chidambaran

2016

Journal of Neuroanaesthesiology and Critical Care

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Avaliação da influência do polimorfismo do códon 16 do receptor beta-2 adrenérgico na incidência de hipotensão arterial e uso de efedrina em grávidas submetidas à anestesia subaracnoidea

Cited by 2 publications

References 25 publications

The effect of beta‐2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery*

The effect of beta‐2 adrenergic receptor haplotype variations on the haemodynamic response following spinal anaesthesia for caesarean delivery*

Genomics relevant to the neuroanaesthesiologist

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