Usos do sulfato de magnésio em obstetrícia e em anestesia

Effectiveness of magnesium sulfate compared to rocuronium for rapid sequence tracheal intubation in adults: clinical randomized trial

“…The hypothesis tested arose from the reported magnesium sulfate action inhibiting acetylcholine release at neuromuscular junction and MS potentiating action of neuromuscular blocking agents. 3 …”

“…First, patients had no known predisposing conditions that would lead to changes in magnesium levels, such as hospital bedridden status, diabetes mellitus, alcoholism, medication use or chronic kidney disease. 3 Second, the objective of a clinical trial is to assess its research protocol under conditions similar to those encountered in daily clinical practice, and preoperative verification of magnesium blood levels is not routine workout.…”

“…Magnesium Sulfate (MS) has been used in anesthesia due to its relevant anesthetic features, such as analgesia, anesthesia and muscle relaxation. 2 , 3 MS has two advantages that can be relevant for tracheal intubation. First, it has anti-adrenergic properties for decreasing suprarenal catecholamine release, leading to protection during laryngoscopy and intubation.…”

“…First, it has anti-adrenergic properties for decreasing suprarenal catecholamine release, leading to protection during laryngoscopy and intubation. 3 Second, there is clinical evidence that MS can potentiate effects of neuromuscular blocking agents and provide tracheal intubation conditions without using these agents. 4 , 5 …”

Ventajas del sulfato de magnesio en anestesiología

“…Encontrándose como cuarto catión más significativo en el organismo y segundo en categoría después del potasio dentro de la célula, teniendo la siguiente distribución 60 -65% del total en el hueso, 27% en el musculo, 6-7% en otras células y 1% en el líquido extracelular, en el plasma bien se pueda encontrar bien sea libre 55 % acomplejado 13% o unido a proteínas 32%. La concentración en suero debe oscilar 1,7 a 2,3 mg/dl (1,4 a 2,0 meq/lt) 2,3 . Su absorción ingerida en intestino delgado es del 90%, el restante se absorbe en el estómago y el intestino grueso, se sabe de dos sistemas de transporte para este catión; uno mediado por transportadores y saturable a bajas concentraciones de 2-4 meq/lt y un sistema de difusión simple que se lleva a cabo cuando aumentan las concentraciones, normalmente las concentraciones que se absorben oscilan entre 45 y 70% de lo ingerido.…”