“…Remifentanil has an organ-independent metabolism and it is considered the opioid of choice for children, and bradycardia and hypotension are less severe in this population of patients than in adults 17 . Bolus of this medication in anesthetic induction is controversial, since remifentanil was developed for continuous infusion, with fast onset and short duration of action 18 . Infusion with bolus doses and manually-controlled were used, but target-controlled infusion pumps can be of more advantage since they correct age-related pharmacokinetic parameters, with the increase in volume of distribution expected in children 19 .…”