Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal

Brocco, Marcos Célio; Paulo, Danilo Nagib Salomão; Baptista, João Florêncio de Abreu; Carraretto, Antônio Roberto; Ferrari, Thiago Antunes; Azevedo, Thiago Caetano V. de; Silva, Alcino Lázaro da

doi:10.1590/s0034-70942008000500005

Cited by 10 publications

(8 citation statements)

References 10 publications

(27 reference statements)

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“…In this study, the washing of the abdominal cavity with the latex of E. tirucalli 12 mg/ml increased the survival of animals with fecal peritonitis to the evaluation period. Similar results were observed in other studies where the death of animals with fecal peritonitis was averted after peritoneal washing with lidocaine 6 and clorexidine 7 .…”

Section: Discussionsupporting

confidence: 90%

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Effects of Topical Treatment With Euphorbia Tirucalli Latex on the Survival and Intestinal Adhesions in Rats With Experimental Peritonitis

Araújo

Mrué

Neves

et al. 2015

ABCD, arq. bras. cir. dig.

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Background: The use of plants of the family Euphorbiaceae, particularly Euphorbia tirucalli (avelós) has been popularly widespread for treating a variety of diseases of infectious, tumoral, and inflammatory. Aim: To demonstrated antimicrobial and immunomodulatory effects of these extracts, evaluating the effect of a topical treatment with an aqueous solution of avelós latex on the survival and on intestinal adhesions in rats with experimental peritonitis. Methods: Peritonitis was induced in 24 Wistar rats, that were randomized into four groups of six as follows: (1) Control group (n=6), no treatment; (2) Antibiotic group (n=6), treatment with a single intramuscular dose of antibiotic Unasyn; (3) Saline group (n=6), the abdominal cavity was washed with 0.9% saline; and (4) E.tirucalli group (n=6), the abdominal cavity was washed with E. tirucalli at a concentration of 12 mg/ml. The animals that died were necropsied, and the time of death was recorded. The survivors were killed on postoperative day 11, and necropsy was subsequently performed for evaluation of the intestinal adhesions. Results: Significant differences were observed in the control and antibiotic groups (p<0.01) with respect to the survival hours when compared with the saline and E. tirucalli groups. There was no significant difference (p>0.05) in the survival of animals in the saline andE. tirucalli groups; however, one animal died in the saline group. Necropsy of the animals in the saline and E. tirucalligroups showed strong adhesions resistant to manipulation, between the intestinal loops and abdominal wall. The remaining groups did not show any adhesions. Conclusions: Topical treatment with E. tirucalli latex stimulated an increased formation of intestinal adhesions and prevented the death of all animals with peritonitis.

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Section: Discussionsupporting

confidence: 90%

“…Subsequently, it was injected into the upper left quadrant of the abdomen solution of 5 ml/kg of fresh faeces of the animals (2 g) diluted in 17 ml saline. Before injection, the suspension was filtered through gauze in order to allow the passage of the inner needle toward the cavity 6 .…”

Section: Methodsmentioning

confidence: 99%

Effects of Topical Treatment With Euphorbia Tirucalli Latex on the Survival and Intestinal Adhesions in Rats With Experimental Peritonitis

Araújo

Mrué

Neves

et al. 2015

ABCD, arq. bras. cir. dig.

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“…Brocco et al 11 reported survival of 100% in rats with peritonitis submitted to peritoneal lavage with bupivacaine. Our hypothesis for a mortality rate of 20% in Group 4 is an increase of morbidity and mortality due to the realization of colic anastomosis.…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, local anesthetics have antimicrobial properties 10 . Brocco et al 11,12 studied the effect of peritoneal lavage with bupivacaine and lidocaine in mice with fecal peritonitis, which prevented death in 100% of the animals during 11 days, while the group submitted to peritoneal lavage with physiological solution showed a mortality rate of 50%.…”

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confidence: 99%

Influence of the peritoneal lavage with bupivacaine on the survival and resistance of colonic anastomoses performed under fecal peritonitis in rats

et al. 2013

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PURPOSE:To evaluate the effects of peritoneal lavage with bupivacaine on survival and initial resistance of anastomosis on distal colon, performed under peritonitis or not. METHODS:Forty rats, weighing from 300 to 350g (321.29±11.31g), were randomly divided in four groups and underwent laparotomy and anastomosis on the distal colon six hours after induction of peritonitis by intraperitoneal injection of autologous fecal material or not. Group 1: No peritonitis and lavage with 3ml NS; Group 2: No peritonitis and lavage with 8 mg.kg-1 (± 0.5 mL) of 0.5% bupivacaine added to 2.5 mL of NS; Group 3: Peritonitis and lavage with 3ml NS; Group 4: Peritonitis and lavage with 8 mg.kg-1 (± 0.5 mL) of 0.5% bupivacaine added to 2.5 mL of NS. Necropsies were performed on the animals that died and the time of death was recorded. Surviving animals were submitted to euthanasia on the fifth post-operative day and Total Energy of Rupture biomechanical test (TER) was applied. RESULTS:Group 4 showed survival increase compared to Group 3, without statistical significance. Group 3 presented the smallest average TER, with statistical significance. CONCLUSION:Peritonitis increased mortality and influenced negatively the resistance of colic anastomosis in rats. Peritoneal lavage with bupivacaine increased anastomotic resistance.

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“…[30][31][32] To the authors' knowledge, pharmacokinetic studies after IP administration of bupivacaine to dogs have not been reported. However, the dose of bupivacaine (2 mg/ kg) used in the present study resulted in serious nonfatal acute toxic effects after IV infusion to conscious sheep 33 and corresponded with a peak arterial blood concentration of 8 µg/mL.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

Benito¹,

Monteiro²,

Beaudry³

et al. 2016

ajvr

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OBJECTIVE To evaluate pharmacokinetics of bupivacaine after IP administration to cats undergoing ovariohysterectomy. ANIMALS 8 healthy cats. PROCEDURES Anesthesia was induced with propofol and maintained with isoflurane. Buprenorphine (0.02 mg/kg, IV) and meloxicam (0.2 mg/kg, SC) were administered. A 20-gauge catheter was inserted into a jugular vein for blood sample collection. A ventral midline incision was made, and a solution of 0.5% bupivacaine (2 mg/kg) diluted with an equal volume of saline (0.9% NaCl) solution (final concentration, 0.25% bupivacaine) was injected into the peritoneal space over the right and left ovarian pedicles and caudal aspect of the uterus before ovariohysterectomy. Cats were monitored for signs of bupivacaine toxicosis. Venous blood samples (2 mL) were collected before (time 0) and 2, 5, 10, 15, 20, 30, 60, 120, and 240 minutes after bupivacaine administration. Plasma bupivacaine concentrations were determined with a liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters were determined by data plotting followed by analysis with a noncompartmental model. RESULTS No signs of bupivacaine toxicosis were observed. Maximum bupivacaine plasma concentration was 1,030 ± 497.5 ng/mL at a mean ± SD value of 30 ± 24 minutes after administration. Mean elimination half-life was 4.79 ± 2.7 hours. Mean clearance indexed by bioavailability and volume of distribution indexed by bioavailability were 0.35 ± 0.18 L•h/kg and 2.10 ± 0.84 L/kg, respectively. CONCLUSIONS AND CLINICAL RELEVANCE Intraperitoneal administration of bupivacaine resulted in concentrations that did not cause observable toxicosis. Studies to investigate analgesic effects for this technique in cats are warranted.

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Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal

Cited by 10 publications

References 10 publications

Effects of Topical Treatment With Euphorbia Tirucalli Latex on the Survival and Intestinal Adhesions in Rats With Experimental Peritonitis

Effects of Topical Treatment With Euphorbia Tirucalli Latex on the Survival and Intestinal Adhesions in Rats With Experimental Peritonitis

Influence of the peritoneal lavage with bupivacaine on the survival and resistance of colonic anastomoses performed under fecal peritonitis in rats

Pharmacokinetics of bupivacaine after intraperitoneal administration to cats undergoing ovariohysterectomy

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