Clonidina por via venosa no pré-operatório do tratamento cirúrgico de catarata: avaliação do benefício clínico

Lemes, Eduardo Tocchetto; Fritz, Fábio Van Der; Homrich, Paulo Henrique Poti; Stolz, Andressa Prestes; Freitas, João Miguel; Fortis, Elaine Aparecida Felix

doi:10.1590/s0034-70942008000400003

Rev. Bras. Anestesiol.

2008

DOI: 10.1590/s0034-70942008000400003

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Clonidina por via venosa no pré-operatório do tratamento cirúrgico de catarata: avaliação do benefício clínico

Eduardo Tocchetto Lemes

Fábio Van Der Fritz²,

Paulo Henrique Poti Homrich³

et al.

Abstract: Clonidine, under the conditions of the present study, showed to be a safe drug and decreased IOP and the intraoperative risk of hypertension without delaying hospital discharge.

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2015

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Cited by 2 publications

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Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders

Vyas¹,

Kakade²,

Chogale³

et al. 2015

CPD

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Symptomatic distresses associated with common ophthalmic infections and their persistence, have remained a tribulation with repeated occurrences. Although being a directly accessible organ, traditional therapeutic strategies exhibiting seemingly fruitful outcome in treatment and prognosis of eye disorders call for improvement in disease intervention. This is due to frequent challenges presented by the ophthalmic environment. Contemporary research has addressed these challenges by applying nanotechnology as a central concept in designing more proficient diagnostic and therapeutic systems for eye ailments. Within such nanosystems (dendrimers, aptamers, metal nanoparticles, etc.), bioactive agents, drugs and genetic materials can be entrapped and these form the key elements that act at the biomolecular stage and bestow a high level of efficacy towards eradication of disease causatives and specificity for recognition and capture aiding diagnostic processes. In the current review, we present researched and patented nanocentric technologies as promising tools in detection and treatment of ophthalmic ailments.

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Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders

Vyas¹,

Kakade²,

Chogale³

et al. 2015

CPD

View full text Add to dashboard Cite

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A comparative evaluation of the effect of intravenous dexmedetomidine and clonidine on intraocular pressure after suxamethonium and intubation

Banga¹,

Singh²,

Dadu³

et al. 2015

Saudi J Anaesth

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Background:In patients with penetrating eye injury and a full stomach, suxamethonium is still used for rapid sequence induction of anesthesia. But its use is associated with the rise in intraocular pressure (IOP) and this can result in permanent vision loss in these patients. Dexmedetomidine and clonidine are two alpha-2 adrenergic agonist drugs which prevent the rise in IOP. The aim of this study is to compare the efficacy of intravenous (i.v.) dexmedetomidine and clonidine in preventing an increase in IOP after administration of suxamethonium and tracheal intubation.Materials and Methods:Sixty patients undergoing elective nonophthalmic surgery under general anesthesia were included in this clinical study. Patients were randomly assigned into three groups to receive 0.5 mcg/kg dexmedetomidine (Group D), 2 mcg/kg clonidine (Group C) or normal saline (Group S) as premedication i.v. over a period of 10 min before induction. IOP, heart rate, and mean arterial pressure were recorded before and after premedication, after suxamethonium, after intubation and then after 5 min.Results:Following administration of dexmedetomidine and clonidine IOP decreased in both groups. After suxamethonium IOP increased in all three groups but it never crossed the baseline in Group D and C. After laryngoscopy and intubation IOP again increased in all three groups but in dexmedetomidine group it never crossed the baseline whereas in clonidine group it was significantly higher than the baseline.Conclusion:Single i.v. dose of dexmedetomidine premedication (0.5 mcg/kg) blunt the IOP and hemodynamic response to suxamethonium injection and tracheal intubation more effectively than single i.v. dose of clonidine premedication (2 mcg/kg).

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Clonidina por via venosa no pré-operatório do tratamento cirúrgico de catarata: avaliação do benefício clínico

Abstract: Clonidine, under the conditions of the present study, showed to be a safe drug and decreased IOP and the intraoperative risk of hypertension without delaying hospital discharge.

Cited by 2 publications

References 4 publications

Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders

Multidimensional Ophthalmic Nanosystems for Molecular Detection and Therapy of Eye Disorders

A comparative evaluation of the effect of intravenous dexmedetomidine and clonidine on intraocular pressure after suxamethonium and intubation

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