Administração inadvertida de 4 mg de morfina por via subaracnóidea: relato de caso

Morais, Bruno; Silva, Yerkes Pereira; Cruvinel, Marcos Guilherme Cunha; Castro, Carlos Henrique Viana de; Hermeto, Marco Victor

doi:10.1590/s0034-70942008000200008

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…Upon investigating the possible mechanism of the antinociceptive activity of cuminaldehyde, it was discovered that the activity was reversed by naloxone, leading to the conclusion that this molecule functions as an agonist of opioid receptors (OR), particularly the µ type [ 17 ]. It is widely recognized that naloxone is a competitive OR antagonist, without agonist action, thus being able to antagonize the adverse effects of opioids or in the treatment of morphine overdose [ 46 ]. According to the in silico results, cuminaldehyde was found to have favorable interactions with the three opioid receptors used, which supports the previous experimental literature.…”

Section: Discussionmentioning

confidence: 99%

Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees

et al. 2023

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Osteoarthritis (OA) is a chronic degenerative disease that has a significant global impact. It is associated with aging and characterized by widespread joint destruction. Cuminaldehyde is a biologically active component of essential oils that has shown promise in the treatment of nociceptive and inflammatory diseases. This study investigated the effects of cuminaldehyde on an experimental model of osteoarthritis induced in rat knees. Cuminaldehyde was found to be as effective as indomethacin in reducing pain in all evaluated tests, including forced walking, functional disability of weight distribution on the legs, and spontaneous pain in animals with osteoarthritis. The knees of animals treated with cuminaldehyde had significantly higher radiographic and histopathological scores than those of animals that did not receive the treatment. Cuminaldehyde also modulated the production of pro-inflammatory cytokines. In vitro assays showed that cuminaldehyde preferentially inhibits COX-2 enzyme activity. In silico studies demonstrated that cuminaldehyde has satisfactory energy affinity parameters with opioid receptors and COX-2. These findings suggest that cuminaldehyde’s anti-inflammatory activity is multifactorial, acting through multiple pathways. Its nociceptive activity occurs via central and peripheral mechanisms. Cuminaldehyde modulates the immune response of the inflammatory process and may be considered a leading compound for the development of new anti-inflammatory and analgesic drugs.

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Section: Discussionmentioning

confidence: 99%

Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees

et al. 2023

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Shortage of Perioperative Drugs

Oliveira

Theilken²,

McCarthy³

2011

Anesthesia &Amp; Analgesia

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Several medications used in clinical perioperative medicine are currently cited on the national shortage list. Medication shortages may be attributed to lack of raw materials, manufacturing issues, and discontinuation of production. Medication shortage has a substantial impact on patient care, and is responsible for creating an environment conducive to an increase in medication errors. Anesthesiologists should be taking an active role with the pharmacy and hospital management to alert caregivers and help to prevent adverse effects on patient care and safety.

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Administração inadvertida de 4 mg de morfina por via subaracnóidea: relato de caso

Abstract: The present report is an alert for the risk of inadvertently switching of drugs during anesthesia, stressing the importance of referring patients being treated for opiate overdose to the ICU, due to the potential adverse reactions.

Cited by 2 publications

References 16 publications

Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees

Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees

Shortage of Perioperative Drugs

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