Avaliação dos efeitos cognitivos da indução inalatória com sevoflurano com ou sem associação com óxido nitroso: estudo comparativo em adultos voluntários

Fernandes, Cláudia Regina; Gomes, Jéssica Marcela de Luna; Cordeiro, Raulysson Almeida do Amaral; Pereira, Kayline de Souza

doi:10.1590/s0034-70942007000300002

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…In addition, Nitrous Oxide is cheaper than volatile anaesthetic gas. 7 Nitrous Oxide (N2O) also has a low anaesthetic potency and has a MAC of 105. Therefore, it has a low blood-gas partition coefficient.…”

Section: Introductionmentioning

confidence: 99%

Nitrous Oxide Influence on Induction of Anaesthesia with Sevoflurane

Haq

Zahoor²,

Jelani³

2023

PAFMJ

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Objective: To find out if the addition of Nitrous Oxide to Sevoflurane significantly reduces induction time and to study the effect of Nitrous Oxide on the frequency of adverse events during induction. Study Design: Quasi-experimental study Place and Duration of Study: Operation Theatre Complex, PAF Hospital Mushaf Sargodha Pakistan from Jul to Sep 2018. Methodology: One hundred adult indoor patients undergoing elective surgeries were included in the study. Their ages were from 18 to 34yrs, and all fell in ASA I and II category. In Group-A, 43 and Group- B, 57 patients were enrolled. Sevoflurane at a high concentration of 8% was given to all patients for induction. In Group-A, 100% oxygen was used as a vehicle, while in Group-B, 70% Nitrous Oxide and 30% oxygen were used as vehicles. Induction time was measured from switching Sevoflurane to when the patients’ arms fell horizontal. We documented adverse effects, including coughing, laryngospasm,bronchospasm, fall in SpO2 <94%, apnea, excitation (head or limb movements), bradycardia and arrhythmias were documented. Results: Mean induction time was 59.00±13.00s and 58.00±8.00s in Groups A and B, respectively. The difference was statistically insignificant (p-value=0.874). Similarly, there was no significant difference in adverse events between the two groups. Conclusion: We concluded that adding Nitrous Oxide has no clinically significant advantage in the induction of anaesthesia with Sevoflurane in adults.

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Section: Introductionmentioning

confidence: 99%

Nitrous Oxide Influence on Induction of Anaesthesia with Sevoflurane

Haq

Zahoor²,

Jelani³

2023

PAFMJ

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Processed electroencephalogram and evoked potential techniques for amelioration of postoperative delirium and cognitive dysfunction following non-cardiac and non-neurosurgical procedures in adults

Punjasawadwong

Chau-In

Laopaiboon

et al. 2018

Cochrane Database of Systematic Reviews

106

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There is moderate-quality evidence that optimized anaesthesia guided by processed EEG indices could reduce the risk of postoperative delirium in patients aged 60 years or over undergoing non-cardiac surgical and non-neurosurgical procedures. We found moderate-quality evidence that postoperative cognitive dysfunction at three months could be reduced in these patients. The effect on POCD at one week and over one year after surgery is uncertain. There are no data available for patients under 60 years. Further blinded randomized controlled trials are needed to elucidate strategies for the amelioration of postoperative delirium and postoperative cognitive dysfunction, and their consequences such as dementia (including Alzheimer's disease (AD)) in both non-elderly (below 60 years) and elderly (60 years or over) adult patients. The one study awaiting classification and five ongoing studies may alter the conclusions of the review once assessed.

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