“…Achondroplasia is the most common cause for dwarfism with an approximate incidence of 1.5 in 10,000-1 in 40,000 live newborns with majority (80%) of the cases due to spontaneous mutation. [ 1 2 3 4 ] Achondroplasia is caused by a genetic mutation of the fibroblast growth factor receptor-3, which affects bone growth due to change in endochondral ossification and leads to bone malformation. [ 5 ] Due to the defective bone growth with extensive skeletal involvement, both general, and neuraxial anesthesia for these patients may be associated with several difficulties including difficult airway, laryngomalacia, technically challenging neuraxial anesthesia, unpredictable spread of local anesthetics in the epidural space and subarachnoid space and compromised pulmonary function.…”