Influência do propofol e do etomidato no bloqueio neuromuscular produzido pelo rocurônio: avaliação pela aceleromiografia

Munhoz, Derli Conceição; Braga, Angélica de Fátima de Assunção; Potério, Glória Maria Braga

doi:10.1590/s0034-70942002000600003

Cited by 3 publications

(1 citation statement)

References 18 publications

(34 reference statements)

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“…Sample size calculation was based on a previous study by Muñoz et al 10 in which the times of rocuronium onset of action were 48.2 ± 1.85 and 51.2 ± 13.8 seconds with propofol and etomidate used respectively as hypnotic agents for induction of anesthesia, representing a percentage difference of 6% between drug associations. Other authors 11 also reported 4.6 ± 0.3 minutes for the onset of cisatracurium (2ED95) in anesthesia with propofol used as hypnotic.…”

Section: Methodsmentioning

confidence: 99%

Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia

Braga¹,

Braga²,

Potério³

et al. 2013

Rev. Bras. Anestesiol.

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Background and objective: Different drugs, including hypnotics, may infl uence the pharmacodynamic effects of neuromuscular blockers (NMB). The aim of this study was to evaluate the infl uence of propofol and etomidate on cisatracurium-induced neuromuscular blockade. Method: We included 60 patients, ASA I and II, undergoing elective surgery under general anesthesia in the study and randomly allocated them into two groups, according to their hypnotic drug: GI (propofol) and GII (etomidate). Patients received intramuscular (IM) midazolam (0.1 mg.kg ). The patients were ventilated with 100% oxygen until obtaining a reduction of 95% or more in the adductor pollicis response amplitude, with subsequent laryngoscopy and tracheal intubation. Neuromuscular function was monitored by acceleromyograhpy. We evaluated the onset of action of cisatracurium, tracheal intubation conditions, and hemodynamic repercussions. Results: The mean time and standard deviations of cisatracurium onset were: GI (86.6 ± 14.3 s) and GII (116.9 ± 11.6 s), with a signifi cant difference (p < 0, 0001). Intubation conditions were acceptable in 100% of GI and 53.3% of GII patients (p < 0.0001). Conclusion: Induction of neuromuscular blockade with cisatracurium was faster, with better intubation conditions in patients receiving propofol compared to those receiving etomidate, without hemodynamic repercussions.

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Section: Methodsmentioning

confidence: 99%

Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia

Braga¹,

Braga²,

Potério³

et al. 2013

Rev. Bras. Anestesiol.

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Creation of pneumoperitoneum: noninvasive monitoring of clinical effects of elevated intraperitoneal pressure for the insertion of the first trocar

et al. 2009

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Transitory, high intraperitoneal pressure (20 mmHg for 5 min) for insertion of the first trocar resulted in changes in HR, MAP, ETCO(2), and ITP that were within the normal range, and no adverse clinical effects were observed. Therefore, the use of transitory, high intraperitoneal pressure is recommended to prevent iatrogenic injury during blind insertion of the first trocar. Nevertheless, it is not clear that this method would be safe in patients with moderate to severe chronic obstructive pulmonary disease.

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Influence of Hypnotics on Cisatracurium-induced Neuromuscular Block. Use of Acceleromyograhpy

Braga

Potério

et al. 2013

Brazilian Journal of Anesthesiology

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Influência do propofol e do etomidato no bloqueio neuromuscular produzido pelo rocurônio: avaliação pela aceleromiografia

Abstract: RESUMO

Cited by 3 publications

References 18 publications

Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia

Influência dos Hipnóticos no bloqueio neuromuscular produzido pelo cisatracúrio: emprego da aceleromiografia

Creation of pneumoperitoneum: noninvasive monitoring of clinical effects of elevated intraperitoneal pressure for the insertion of the first trocar

Influence of Hypnotics on Cisatracurium-induced Neuromuscular Block. Use of Acceleromyograhpy

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