Anestesia na Pré-Eclâmpsia

Ganem, Eliana Marisa; Castiglia, Yara Marcondes Machado

doi:10.1590/s0034-70942002000400013

Cited by 7 publications

(4 citation statements)

References 87 publications

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“…Magnesium sulfate (MgSO 4 ) has been shown to have therapeutic effects in PE and reduces the release of acetylcholine in the 1 neuromuscular junction, which causes the muscles to relax, 16 increases the synthesis of prostacyclins, increases vasodilation by inhibiting angiotensin-converting enzyme 17 and improves sedation of the nervous system. 18 In addition, Dowling et al 19 found that administration of MgSO 4 inhibited LPS-induced excessive inflammation at the maternal-fetal interface.…”

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confidence: 99%

Increased neuronal seizure activity correlates with excessive systemic inflammation in a rat model of severe preeclampsia

et al. 2016

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Preeclampsia (PE), one of the most common disorders of pregnancy, is characterized by hypertension and albuminuria. In severe cases, PE results in eclampsia-like seizures. Studies have suggested that severe PE is related to an exaggerated systemic inflammatory response, which may increase sensitivity to seizures. In the current study, we investigated whether the seizure activity of neurons was enhanced under excessive systemic inflammation. We also sought to determine whether MgSO could reduce the effects of systemic inflammation on seizure activity after electrical stimulation in a lipopolysaccharide (LPS)-induced model of PE. In addition to pregnancy outcomes, we analyzed biochemical parameters to ascertain whether our PE model was successful. Enzyme-linked immunosorbent assay analysis revealed that the levels of inflammatory cytokines (tumor necrosis factor (TNF)-α and interleukin (IL)-1β) were significantly higher in the LPS-treated rats than in the untreated rats. After electrical stimulation, behavioral assessments showed that the LPS-treated rats that were not treated with MgSO had the shortest latency period to develop a seizure and the longest seizure duration. The electroencephalographic (EEG) recordings in the hippocampus demonstrated that this group also had the highest EEG amplitude. MgSO treatment significantly decreased both TNF-α and IL-1β concentrations, increased the latency to develop a seizure, decreased the seizure duration and shortened the EEG amplitude. These results suggest that neuronal seizure activity and systemic inflammation are increased in severe PE. In addition, MgSO treatment reduced systemic inflammation and seizure severity. We conclude that excessive systemic inflammation in PE promotes eclampsia seizures, which can be attenuated by MgSO treatment.

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confidence: 99%

Increased neuronal seizure activity correlates with excessive systemic inflammation in a rat model of severe preeclampsia

et al. 2016

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“…Diversos autores encontraram aumento abrupto da FC nas primeiras quatro semanas de gestação, seguido por um aumento gradual, atingindo um platô de aproximadamente 15 batimentos por minuto acima dos valores da FCR no estado não gravídico (26,27,28). Esse aumento pode ser causado por ajustes vasculares e hemodinâmicos decorrentes da gestação (28).…”

Section: Discussionunclassified

Efeitos do tratamento fisioterapêutico na pré-eclampsia

2010

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ResumoIntrodução: As síndromes hipertensivas gestacionais (SHG) caracterizam uma gestação de alto risco, ocorrendo em 10% a 22% das gestantes, e estando a ela relacionadas as intercorrências clínicas maternofetais. Objetivos: Este trabalho teve por objetivo geral realizar uma pesquisa bibliográfi ca sobre o efeito do tratamento fi sioterapêutico na pré-eclampsia e, em específi co, avaliar os efeitos do tratamento fi sioterapêutico na diminuição da pressão arterial em gestantes que apresentam fatores de risco para desenvolverem a pré-eclampsia. Metodologia: Foi realizada uma pesquisa bibliográfi ca no período de outubro de 2005 a agosto de 2008, tendo como fonte de pesquisas bases de dados eletrônicos, tais como Bireme, Portal da Pesquisa (Capes) e biblioteca particular. Resultados: Foram encontradas 21 referências, entre livros e periódicos nacionais e internacionais indexados com período de publicação entre 1998 e 2008. Conclusão: Foi verifi cado que a fi sioterapia desempenha um papel importante no tratamento das SHG, principalmente naquelas gestantes que apresentam HAS antes da gestação, pois o exercício aeróbico contribui para que os níveis de pressão arterial sejam controlados, e também cabe ao fi sioterapeuta orientar quanto a mudanças nos hábitos de vida, a fi m de que os fatores de risco sejam diminuídos.[P] Palavras-chave: Hipertensão induzida pela gravidez. Pré-eclampsia. Fisioterapia.[B] Abstract Introduction: The pregnancy high pressure syndromes (PHS) characterize a pregnancy of high risk, occurring in 10% to 22% of the pregnancies, and being related to it the clinical complications to mother and baby. Objectives:Fisioter Mov. 2010 out/dez;23(4):663-72 de Souza VFF, Dubiela Â, Serrão Jr NF. 664 This work had for general objective to carry through a bibliographical research on the effect of the physical therapy treatment in the daily before eclampsia and, in specifi c, to evaluate the effect of the physical therapy treatment in the reduction of the arterial pressure in pregnancy that present risk factors to develop the daily before eclampsia. Methodology: The October of 2005 was carried through a bibliographical research in the period of November of 2009, having as source of research electronic Bireme, Portal of Search databases, and particular library. Results: Twenty-one references between books and index national and international periodic with period of publication between 1998 and 2008 had been found. Conclusions: It was verifi ed that the physical therapy plays an important role in the treatment of PHS, mainly in those pregnancies that present high pressure systemic before the pregnancy, therefore the aerobic exercise also contributes so that the levels of arterial pressure are controlled, and it is also the physiotherapist oriented as the changes in habits of life so that the risk factors are diminished. [K]

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“…Medicine has not elucidated completely the mechanism of action of magnesium sulfate used therapeutically 13 . Some of the following propositions have been developed over the years: a) Inhibition of the release of acetylcholine in the neuromuscular junction 9,14 leading to muscle relaxation, which has been known since the 1950s 3 . Hypermagnesemia decreases the sensitivity of the motor plate to acetylcholine and the amplitude of terminal end-plate potential 9 .…”

Section: Physiology and Pharmacologic Effetcsmentioning

confidence: 99%

“…It has been postulated that the anticonvulsant property of magnesium sulfate is due to the blockade of NMDA receptors 5,14 .…”

Section: Obstetric Applicationsmentioning

confidence: 99%