Resultados de um programa de prevenção da cegueira pela retinopatia da prematuridade na Região Sul do Brasil

Filho, João Borges Fortes; Barros, Cristiano Koch; Costa, Marlene Coelho da; Procianoy, Renato Soibelmann

doi:10.1590/s0021-75572007000400005

Cited by 14 publications

References 4 publications

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Predicting Proliferative Retinopathy in a Brazilian Population of Preterm Infants With the Screening Algorithm WINROP

Hård

Löfqvist²,

Filho³

et al. 2010

Arch Ophthalmol

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To retrospectively validate the WINROP (weight, insulinlike growth factor I, neonatal, retinopathy of prematurity [ROP]) algorithm in a Brazilian population. WINROP aims to predict ROP and is based on longitudinal weight measurements from birth until postmenstrual age 36 weeks. WINROP has predicted 100% of severe ROP in 3 neonatal intensive care unit settings in the United States and Sweden. Methods: In children admitted to the neonatal intensive care unit at Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, from April 2002 to October 2008, weight measurements had been recorded once a week for children screened for ROP, 366 of whom had a gestational age of 32 weeks or less. The participating children had a median gestational age of 30 weeks (range, 24-32 weeks) at birth and their median birth weight was 1215 g (range, 505-2000 g). Results: For 192 of 366 children (53%), no alarm or lowrisk alarm after postmenstrual age 32 weeks occurred. Of these, 190 of 192 did not develop proliferative disease. Two boys with severe sepsis who were treated for ROP received low-risk alarms at postmenstrual age 33 and 34 weeks, respectively. The remaining 174 children (47%) received high-or low-risk alarms before or at 32 weeks. Of these infants, 21 (12%) developed proliferative ROP. Conclusions: In this Brazilian population, WINROP, with limited information on specific gestational age and date of weight measurement, detected early 90.5% of infants who developed stage 3 ROP and correctly predicted the majority who did not. Adjustments to the algorithm for specific neonatal intensive care unit populations may improve the results for specific preterm populations.

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Predicting Proliferative Retinopathy in a Brazilian Population of Preterm Infants With the Screening Algorithm WINROP

Hård

Löfqvist²,

Filho³

et al. 2010

Arch Ophthalmol

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The influence of gestational age on the dynamic behavior of other risk factors associated with retinopathy of prematurity (ROP)

Filho

Eckert

Valiatti

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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BackgroundImproved survival of preterm neonates has increased the incidence of retinopathy of prematurity (ROP) in many middle-income countries.AimThis study aimed to verify the main risk factors for the development of ROP according to different gestational age (GA) groups.MethodsA prospective cohort study including infants weighing ≤1,500 g or GA ≤32 weeks at birth was conducted. The main clinical outcomes were the occurrence of any stage of ROP and severe ROP. The perinatal variables considered for the study were: birth weight; GA; gender; to be small for GA (SGA); weight gain from birth to the sixth week of life; use of oxygen in mechanical ventilation or nasal CPAP; multiple gestations; therapeutic use of surfactant, indomethacin, and erythropoietin; occurrence of sepsis, meningitis, intraventricular hemorrhage, and patent ductus arteriosus; need for and volume of blood transfusion; and 10-min Apgar score. The patients were divided into three groups according to GA: (group 1) infants of GA ≤28 weeks at birth (n = 100); (group 2) infants of GA = 29–31 weeks at birth (n = 215); and (group 3) infants of GA ≥32 weeks at birth (n = 152).ResultsA total of 467 newborn infants were included. Mean BW and GA in the total cohort were 1,216.5 g (±278.3) and 30.3 weeks (±2.2), respectively. Gestational age groups were not matched for BW and SGA. Any stage of ROP occurred in 111 patients (23.8%) and 24 (5.1%) patients developed severe ROP. Only BW and volume of blood transfusion were significant factors for the occurrence of any stage of ROP in all groups. In group 1, GA, the twin situation, and use of erythropoietin were statistically significant factors. In group 2, only GA and need for blood transfusion were significant. In group 3, use of oxygen in mechanical ventilation, sepsis, and need for blood transfusion were significant for ROP onset. The logistic regression determined that patients in groups 2 and 3 were less likely to develop ROP than patients in group 1.ConclusionsPatients in groups 1 and 2 developed ROP due to general immaturity, whereas bigger babies, of GA ≥32 weeks, developed ROP because they were “sicker” babies with more comorbidities.

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Eye and Vision Disorders

Campomanes¹,

Binenbaum²

2018

Avery's Diseases of the Newborn

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Resultados de um programa de prevenção da cegueira pela retinopatia da prematuridade na Região Sul do Brasil

Cited by 14 publications

References 4 publications

Predicting Proliferative Retinopathy in a Brazilian Population of Preterm Infants With the Screening Algorithm WINROP

Predicting Proliferative Retinopathy in a Brazilian Population of Preterm Infants With the Screening Algorithm WINROP

The influence of gestational age on the dynamic behavior of other risk factors associated with retinopathy of prematurity (ROP)

Eye and Vision Disorders

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