IgE total em alergia respiratória e infecção por helmintos

Abstract

The paper published by Medeiros et al. 1 meets all of the journal's editorial prerequisites, such as Ethics Committee approval and sample size calculations to obtain a "convenience sample" adequate for a valid statistical analysis. It has contributed information to the subject, but further comments are necessary to better explain the issue. The antigenic determinants in parasites vary depending on their stage of development, from egg, through embryo and larva to the adult worm. The adult parasite has countless antigens capable of inducing humoral and cellular immune response, generally with polyclonal stimulation, but the presence of IgE antibodies to Ascaris provides no indication of which antigens or from which phase they have resulted. The authors claim, without offering any references, that "Infected atopic individuals show exacerbation of allergic symptoms immediately after anti-helminthic therapy." Whether this is a personal experience or one reported by other authors, what would be the approach to take in cases of infection by parasites in asthmatics to avoid exacerbations due to anti-helmintic treatment? In an editorial on the article in question, Sorensen & Sakali, 2 pointed out the high prevalence of parasitic infection in the cohort of atopic patients and the lack of certain controls that would have been of interest if included, in order to determine whether parasitic infections offer protection against allergic manifestations, or vice-versa.

Association between functional neurometry test results and blood biomarkers indicative of anaemia, subclinical inflammation, and endothelial dysfunction

“…However, when it is separated from the context of inflammation by pathogens, several authors justify the classification of subclinical inflammation by the presence of pollutants 24 and foods that contain allergenic and inflammatory components. 25 The total IgE biomarker can be indicated to investigate the occurrence of allergic reactions, in addition to being suitable also in suspected diseases caused by parasites 26 or even bronchopulmonary aspergillosis, 27 which is a fungal disease that affects the respiratory system.…”