Fatores de risco da hepatopatia da fibrose cística

Abstract

The risk of developing liver disease is higher among patients diagnosed at an early age and those with worse clinical status as assessed by the Shwachman score, indicating that liver involvement might be part of a more severe form of the condition. These patients merit greater attention in terms of screening for liver disease and should be given treatment with ursodeoxycholic acid earlier in the event of abnormal findings.

Clinical and Genetic Risk Factors for Cystic Fibrosis-Related Liver Disease in Egyptian Cf Children: A Single-Center Experience

“…16 In a study regarding risk factors leading to CFLD in a large-scale cohort of patients in France concluded that male sex and long duration of illness are significant risk factors for developing CFLD, they also found that CFLD occurrence elevated by 1-2 percent every year from birth until the age of 25 years of age. 17 18,19 CFLD often manifests during the two decades of life. The majority of CF children tend to develop a degree of steatosis.…”

Desafios no manejo da fibrose cística

“…Apesar do pulmão do paciente com FC ser histologicamente normal ao nascimento, infiltrados respiratórios podem ser vistos durante o período neonatal, podendo ser observada após poucas semanas de vida, seguida de um progressivo comprometimento das vias aéreas. Devido aos problemas pulmonares e a queda de imunidade que a FC causa, um dos principais desafios no manejo dos portadores de FC é a diversidade de microrganismos patogênicos, que podem afetar o portador, tendo em vista que conforme a doença progride, os riscos aumentam 1,[3][4][5] .…”