Manifestações músculo-esqueléticas como apresentação inicial das leucemias agudas na infância

Barbosa, Cássia Maria Passarelli Lupoli; Nakamura, C.H.; Terreri, Maria Teresa; Lee, Maria Lúcia de Martino; Petrilli, Antônio Sérgio; Hilário, Maria Odete Esteves

doi:10.1590/s0021-75572002000600007

Cited by 23 publications

(11 citation statements)

References 13 publications

(27 reference statements)

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“…The commonest malignancy in children is acute leukemia, which may be found primarily by the bony lesions [2][3][7][11][12]. Bone pain due to proliferation of bone marrow, pressure effect, compress fractures and osteoporosis may ensue [3][7][13].…”

Section: Discussionmentioning

confidence: 99%

“…Bone pain due to proliferation of bone marrow, pressure effect, compress fractures and osteoporosis may ensue [3][7][13]. …”

Section: Discussionmentioning

confidence: 99%

“…Chromosomal abnormalities such as Down, Bloom and Fanconi Syndrome and also ataxia telangiectasia are prone to this malignancy [1][4][5]. Although leukemia may present with pallor, petechia, ecchymosis in skin and mucus membranes, growing skeleton is an important site for proliferation of leukemic cells; therefore, during the course of disease, tenderness and multiple areas of bone destruction and repair due to infiltration of leukemic cells in the bone marrow may be seen [6][7]. More common radiographic findings which have been reported in the literature are generalized reduced bone density, metaphyseal lucent band, lytic bone lesions, metaphyseal cortical bone erosions, collapsed vertebra and widening of sutures and periosteal reactions [6][7] which have been seen in our cases with variable frequencies (Figure 1, 2, 3, 4, 5, 6, 7, 8, 9, & 10).…”

Section: Introductionmentioning

confidence: 99%

“…Due to widespread red bone marrow in childhood, more than 50% of children with leukemia reveal skeletal abnormalities; however, this is less than 10% in adults [7][8]. In addition, bone involvement had no worse prognosis in comparison to cases without bone involvement [6].…”

Section: Introductionmentioning

confidence: 99%

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Bony Lesions in Pediatric Acute Leukemia: Pictorial Essay

et al. 2012

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Acute leukemia is the most common malignancy in childhood, which mainly involves children less than 15 years of age. The growing skeleton is the main site of involvement in children. Leukemic cells proliferate within the massive red bone marrow in children. So besides the pallor, petechia, purpura and ecchymosis in the skin and mucosal surfaces, bone pain and other bony lesions are other manifestations of leukemia.On the other hand, bony lesions are more prevalent in children than adults with no poor prognosis in comparison to patients without bone lesions. These bony lesions may precede other laboratory tests so familiarity with these presentations is very important for earlier diagnosis.In this pictorial essay, we tried to gather the most common bony lesions that may be seen in acute leukemia in different cases admitted to our hospital with general malaise and localized tenderness and discomfort leading us to perform plain X-ray for further evaluation. Finding these bony lesions helps clinicians to reach the diagnosis quickly. These findings include metaphyseal lucent band and erosion, periosteal reaction, small lucent bone lesion and permeative appearance, reduced bone density and collapsed vertebra.

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Section: Discussionmentioning

confidence: 99%

“…Bone pain due to proliferation of bone marrow, pressure effect, compress fractures and osteoporosis may ensue [3][7][13]. …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bony Lesions in Pediatric Acute Leukemia: Pictorial Essay

et al. 2012

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“…The Acute Lymphoblastic Leukemia (ALL) is the most common childhood cancer, accounting for 25% of cancers 0-14 years and constitutes 85% of infant leukemias (Barbosa et al, 2002), already Chronic Lymphocytic Leukemia (CLL) is quite prevalent in adults with age range 67-72 years. The CLL has caused concern, since it is characterized by clonal proliferation and accumulation of malignant B lymphocytes mature and considered an incurable disease.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

Redox Modifications and Hematological Neoplasms-an Overview

Campos¹

2014

American Journal of Immunology

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Due to our current interest in the study of the relationship between hematological malignancies and oxidative stress, in this review we addressed the recent finding regarding this issue, focusing on the clinical findings concerning the oxidative status of patients diagnosed with hematological cancers. This study is a descriptive review of the literature. For the theoretical scientific background, we used the electronic PubMed search engines. It is possible to find several studies involving oxidative stress and hematological cancer, analyzing the many ways regarding the imbalance of excessive free radical production and its neutralization by antioxidants. The present review highlights the need for studies to understand the main role of oxidative stress as a cause or consequence of hematological neoplasms, as well as its participation as beneficial for either the host or tumor cells.

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Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy

et al. 2018

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Acute lymphoblastic leukemia (ALL) is the most common childhood neoplasia and may present with arthralgia and arthritis, with the risk of misdiagnosis and diagnostic delay. We describe in detail arthropathy (arthritis/arthralgia) among children with leukemia as the children's laboratory results, misdiagnosis, and treatment before the diagnosis of ALL and the diagnostic delay. In this retrospective cohort study, we reviewed records of 286 children aged 1-15 years diagnosed with ALL from January 1992 to March 2013. We identified 26 children with arthralgia and 27 children with arthritis. The majority of the children had one or two joints involved (arthralgia 72%, arthritis 42%), and most often hips and knees. Morning stiffness was not reported. Imaging of affected joints was included in the initial workup of 77% of children with ALL and arthropathy, and 66% was abnormal. Misdiagnosis as JIA occurred in 26% and 71% of these children received treatment with intraarticular corticosteroids. The diagnostic delay was 3 weeks longer for the children with arthritis than those with arthralgia (median 54 vs 36 days), primarily as a consequence of a longer first doctor's delay. Compared to the children with arthralgia, the children with arthritis were more often misdiagnosed and treated with intraarticular steroid before the diagnosis of ALL. They also had longer diagnostic delay, primarily as a consequence of a longer first doctor's delay.

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Manifestações músculo-esqueléticas como apresentação inicial das leucemias agudas na infância

Cited by 23 publications

References 13 publications

Bony Lesions in Pediatric Acute Leukemia: Pictorial Essay

Bony Lesions in Pediatric Acute Leukemia: Pictorial Essay

Redox Modifications and Hematological Neoplasms-an Overview

Characteristics of children with acute lymphoblastic leukemia presenting with arthropathy

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