ECEP, ECET, ECEA, ECEH, ECEI, ECAD: a E. coli revisitada no contexto da diarréia aguda

Sabrá, Aderbal

doi:10.1590/s0021-75572002000100003

Cited by 1 publication

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“…Escherichia coli is active in the human intestinal tract [13]; it participates in vitamin K 2 synthesis and in defense against pathogenic bacteria [14]. Escherichia coli can cause severe food poisoning and more severe conditions such as peritonitis [15], meningitis, and urinary infections [16]. In E. coli strains, production of extended-spectrum β-lactamases (ESBL) [17] hydrolyzes most penicillins, cephalosporins, and monobactams (aztreonam), the cephamycins and carbapenems being among the few exceptions [18].…”

Section: Introductionmentioning

confidence: 99%

“…In the current work, a set of sixteen caffeic acid ester derivatives were evaluated for their in vitro antibacterial activity against strains of Staphylococcus aureus and Escherichia coli. Methyl caffeate (1), ethyl caffeate (2), propyl caffeate (3), isopropyl caffeate (4), methoxy-ethyl caffeate (5), butyl caffeate (6), pentyl caffeate (7), isopentyl caffeate (8), decyl caffeate (9), diphenylmethyl caffeate (10), 4chlorobenzyl caffeate (11), 4-methoxybenzyl caffeate (12), (di-(4-chlorobenzyl)) caffeate (13), (di-(4-methoxybenzyl)) caffeate(14), benzyl caffeate(15), and 4-methylbenzyl caffeate (16) each with differing substitutions on the ester side chain (R 1 ) and the hydroxyl of the para position of the caffeic ring (R 2 ) were tested. e results were expressed as minimal inhibitory concentration (MIC) in μM.…”

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confidence: 99%

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Synthesis, Antibacterial Evaluation, and QSAR of Caffeic Acid Derivatives

Araújo

Pêssoa

Lira

et al. 2019

Journal of Chemistry

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The present study evaluates the antibacterial effects of a set of 16 synthesized caffeic acid ester derivatives against strains of Staphylococcus aureus and Escherichia coli, as well as discusses their structure-activity relationship (SAR). The antibacterial assays were performed using microdilution techniques in 96-well microplates to determine minimal inhibitory concentration (MIC). The results revealed that five of the compounds present strong to optimum antibacterial effect. Of the sixteen ester derivatives evaluated, the products with alkyl side chains, as propyl caffeate (3), butyl caffeate (6), and pentyl caffeate (7), presented the best antibacterial activity with MIC values of around 0.20 μM against Escherichia coli and only butyl caffeate (6) showing the same MIC against Staphylococcus aureus. For products with aryl substituents, the best MIC results against the tested strain of Escherichia coli were 0.23 µM for (di-(4-chlorobenzyl)) caffeate (13) and 0.29 µM for diphenylmethyl caffeate (10) and all were less active against the Staphylococcus aureus strain. Preliminary quantitative structure-activity relationship (QSAR) analyses confirmed that certain structural characteristics, such as a median linear carbon chain and the presence of electron withdrawal substituents at the para position of the aromatic ring, help potentiate antibacterial activity.

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