Efeitos da asfixia perinatal sobre os hormônios tireoidianos

Pereira, Denise N.; Procianoy, Renato Soibelmann

doi:10.1590/s0021-75572001000300007

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…In this s t u d y, seizures were found in 52.4% of patients and w e re more frequent in those with Apgar score ≤ 5 at the fifth minute and severe HIE, except for one case with Apgar score 7. The same percentage value was found by Pereira in a study with asphyxiated infants at the same neonatology service 23 .…”

Section: Discussionsupporting

confidence: 86%

S100B protein related neonatal hypoxia

Martins¹,

Rotta

Portela

et al. 2006

Arq. Neuro-Psiquiatr.

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-Biochemical markers have played an increasingly relevant role in the assessment of neonatal asphyxia. The S100B protein is particularly important in re s e a rch conducted in this field. The purpose of this study was to underline the importance of the S100B protein in the assessment of term newborn infants with hypoxic-ischemic encephalopathy, as well as to relate it to other substances also involved in the ischemic p rocess. An assessment was made from September 2003 to October 2004 of 21 term newborn infants who developed hypoxic-ischemic encephalopathy. Samples were collected on the 1 s t and 4 t h day of life and S100B p rotein and lactate concentrations were calculated using the immune cytochemical method. A positive relationship was found between the two substances. Additionally, a comparison between the two substances showed a statistically significant correlation.KEY WORDS: S100B, hypoxic-ischemic encephalopathy, newborn, asphyxia.Relação da proteína S100B com a hipóxia neonatal RESUMO -A participação de marcadores bioquímicos na avaliação de quadros de asfixia neonatal é cada vez mais relevante. A proteína S100B é de particular importância neste campo. O objetivo deste estudo foi procurar destacar a importância da proteína S100B na avaliação de recém-nascidos a termo com quadro de encefalopatia hipóxico-isquêmica, assim como correlacionar com outras substâncias que também participam do processo isquêmico. Foram analisados 21 casos de recém nascidos a termo que desenvolveram encefalopatia hipóxico-isquêmica no período de setembro de 2003 a outubro de 2004. Realizadas coletas no 1º e 4º dia de vida e dosadas, por método imunocitoquímico, a proteína S100B e o lactato. Observouse correlação positiva entre as duas substâncias, assim como quando comparadas entre si nas suas respectivas dosagens, obteve-se significância estatística. PALAVRAS-CHAVE: S100B, encefalopatia hipóxico-isquêmica, recém-nascido, asfixia.

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Section: Discussionsupporting

confidence: 86%

S100B protein related neonatal hypoxia

Martins¹,

Rotta

Portela

et al. 2006

Arq. Neuro-Psiquiatr.

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“…Another important finding that warrants special attention is the 5-minute Apgar score. Its association with asphyxia is well known and, based on our findings, this factor is associated with five fold odds of an abnormal TSH concentration on day 3 of life [10]. Thus, the 5-minute Apgar score is an important factor that may serve as a marker to help clinicians decide whether to measure TSH during this period.…”

Section: Discussionmentioning

confidence: 55%

Do the Infant Respiratory Distress Syndrome and Presumed Sepsis affect Thyroid Function in Preterm Newborns within the First 10 Days of Life?

2017

J Paediatr Child Care

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Janeiro, Brazil, who required NICU care for more than 48 hours and remained hospitalized for 10 days or more between May 2013 and April 2016. An intentional non probability sampling strategy was used, whereby infants were enrolled systematically and consecutively.We excluded all patients with congenital malformations and those whose guardians did not provide written informed consent for participation.Gestational age (in weeks), birth weight (in grams), and 1-minute and 5-minute Apgar scores were obtained from the neonates' hospital records.The preterm neonates enrolled in the study were divided into four groups: 1. No IRDS or sepsis. These formed the Control Group (CG); 2. Those diagnosed with IRDS (IG); 3. Those with presumed sepsis (SG); and 4. Those with both IRDS and Presumed Sepsis (ISG).Gestational age was assessed by the new Ballard method. When this was not possible, it was based on the date of last menstrual period or on the findings of the most recent obstetric ultrasound, as recorded in the mother's medical record.For diagnosis of IRDS, we considered chest X-ray findings and the individual and clinical evaluation of the patient regarding the need for supplemental oxygen and the presence of respiratory distress.For diagnosis of presumed sepsis, we used the hematological scoring system of Rodwell [6]. In this system, the diagnosis of presumed neonatal sepsis is established by the presence of three or more of the following criteria in the peripheral blood: Leukocytosis (>25,000) or Leukopenia (<5,000); increase in immature neutrophils; Immature-to-Mature (I:M) neutrophil ratio > 0.3; Immature-to-Total (I:T) neutrophil ratio > 0.2; platelet count less than or equal to 100.000/mm 3 ; and presence of major degenerative changes in neutrophils. The presence of two or fewer criteria is considered negative for diagnosis, and is associated with a 99% likelihood of sepsis being absent.

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Efeitos da asfixia perinatal sobre os hormônios tireoidianos

Cited by 2 publications

References 21 publications

S100B protein related neonatal hypoxia

S100B protein related neonatal hypoxia

Do the Infant Respiratory Distress Syndrome and Presumed Sepsis affect Thyroid Function in Preterm Newborns within the First 10 Days of Life?

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