Psychiatric disorders in patients with systemic lupus erythematosus

Asano, Nadja Maria Jorge

doi:10.1590/s0004-282x2013000300017

Cited by 4 publications

(2 citation statements)

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“…6,24,25 Of those, depression is one of the most common mental illnesses. 26 Similar to present findings, the recent studies suggest that the point prevalence of depressive disorder in SLE is up to 39%, 27 while the lifetime prevalence is up to 69%, 28,29 which is far more prevalent than that of the general population in which the point and lifetime prevalence is 6.1% and 10.3%, respectively. 1 The high morbidity of depression in SLE warrants continuing research and expansion of efforts in the clinical setting to optimize treatments.…”

Section: Discussionsupporting

confidence: 90%

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Maneeton

Louthrenoo

2013

European Psychiatry

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Objective: The purpose of this study was to estimate the prevalence and examine the predictors of depression in patients with systemic lupus erythematosus (SLE). Methods: This cross-sectional study was conducted in the rheumatology clinic of a university hospital. All SLE patients that met the revised American College of Rheumatology (ACR) classification were included in the study. Sociodemographic data and medications were recorded. Disease activity for SLE was assessed with the Mexican-SLE Disease Activity Index (Mex-SLEDAI). All subjects were screened for anxiety and depression by using the Hamilton Anxiety Rating Scale (HAM-A) and the 17-item version of the Hamilton Depression Rating Scale (HAM-D17). Multiple linear regression analyses were used to determine predictors of depressive disorder. Results: A total of 62 SLE (61 females and 1 male) patients participated in the study. Based on HAM-D17 and HAM-A, rates of depression and anxiety in SLE patients were 45.2% and 37.1%, respectively. The multiple linear regression analysis revealed that HAM-A score and younger age were significant predictors of depression in SLE patients. Conclusion:The findings suggest that depression and anxiety are common in SLE patients. In addition, higher levels of anxiety and a younger age may increase the risk of depression. Because of the small sample size, further studies should be conducted to confirm these results.

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Section: Discussionsupporting

confidence: 90%

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Maneeton

Louthrenoo

2013

European Psychiatry

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show abstract

“…Of those, depression is one of the most common mental illnesses 26. Similar to present findings, the recent studies suggest that the point prevalence of depressive disorder in SLE is up to 39%,27 while the lifetime prevalence is up to 69%,28,29 which is far more prevalent than that of the general population in which the point and lifetime prevalence is 6.1% and 10.3%, respectively 1.…”

Section: Discussionsupporting

confidence: 88%

Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Maneeton¹,

Maneeton²,

Louthrenoo³

2013

NDT

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ObjectiveThe purpose of this study was to estimate the prevalence and examine the predictors of depression in patients with systemic lupus erythematosus (SLE).MethodsThis cross-sectional study was conducted in the rheumatology clinic of a university hospital. All SLE patients that met the revised American College of Rheumatology (ACR) classification were included in the study. Sociodemographic data and medications were recorded. Disease activity for SLE was assessed with the Mexican-SLE Disease Activity Index (Mex-SLEDAI). All subjects were screened for anxiety and depression by using the Hamilton Anxiety Rating Scale (HAM-A) and the 17-item version of the Hamilton Depression Rating Scale (HAM-D17). Multiple linear regression analyses were used to determine predictors of depressive disorder.ResultsA total of 62 SLE (61 females and 1 male) patients participated in the study. Based on HAM-D17 and HAM-A, rates of depression and anxiety in SLE patients were 45.2% and 37.1%, respectively. The multiple linear regression analysis revealed that HAM-A score and younger age were significant predictors of depression in SLE patients.ConclusionThe findings suggest that depression and anxiety are common in SLE patients. In addition, higher levels of anxiety and a younger age may increase the risk of depression. Because of the small sample size, further studies should be conducted to confirm these results.

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Distinctive gene expression profile in women with history of postpartum depression

Landsman¹,

Aidelman²,

Smith³

et al. 2017

Genomics

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Postpartum depression (PPD) is a disease which incorporates a variety of depressive states differing in nature and severity. To assist in the understanding of the pathogenesis of the disease, we aimed to ascertain a molecular mechanism underlying PPD development. We applied microarray technology to characterize gene expression of euthymic women with a history of PPD and compared the results with healthy controls. Our study demonstrated that women who considered euthymic on a clinical level, in fact, had an altered molecular profile when compared to participants with no PPD history. We identified nine genes significantly distinguished expression in post- depressive women; they may serve as a diagnostic tool for the detection of a predisposition to PPD. Our findings contribute significantly to the understanding of PPD etiology and its pathogenesis, offer a plausible explanation for the risk of the PPD recurrence, and may also contribute to clinical treatment.

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Psychiatric disorders in patients with systemic lupus erythematosus

Cited by 4 publications

References 0 publications

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Distinctive gene expression profile in women with history of postpartum depression

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