Recurrent post-ictal hyperthermia

Rocha, Sofia; Sousa, Filipa; Pinho, João; Maré, Ricardo; Machado, Álvaro

doi:10.1590/s0004-282x2012001200013

Cited by 3 publications

(3 citation statements)

References 6 publications

(13 reference statements)

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“…It has been suggested that epileptic activity, which especially occurs in mesial temporal structures, could affect thermoregulatory centers by spreading to the pre-optic area in the hypothalamus. The vagal nerve nucleus (nucleus tractus solitarius) may be affected during seizures or seizures may give rise to pyrogens in many regions of the brain such as the neocortex, amygdala, and hippocampus (52). In our series, high fever was detected in 2 patients in both history and in the pre-and post-ictal period during VEM.…”

Section: Peri-ictal Hyperthermiamentioning

confidence: 54%

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Current View of Autonomic Findings During Epileptic Seizures

Baysal-Kıraç¹,

Baykan²

2015

tnd

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147Autonomic findings during epileptic seizures frequently associate other ictal symptoms or may appear isolated. These changes are often overshadowed by other dramatic motor symptoms and not recognized. Cardiovascular system changes are thought to play a particular role in sudden unexplained death in epilepsy (SUDEP). In the literature, information about the features of peri-ictal autonomic symptoms and their lateralizing value are controversial. It is important to identify patients who are at high risk for SUDEP and plan early and appropriate medical treatment, as well as epilepsy surgery options to reduce mortality related with seizures. This paper will review the literature of the frequency of peri-ictal autonomic findings and their lateralizing and localizing information with didactic case examples. Furthermore, the relation between cardiac rhythm disorders, other electroclinical data, and risk of SUDEP will be evaluated.

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Section: Peri-ictal Hyperthermiamentioning

confidence: 54%

“…Hyperthermia can occur in rare cases of generalized or focal or non-convulsive seizures (51,52). Peri-ictal hyperthermia has no lateralizing or localizing value.…”

Section: Peri-ictal Hyperthermiamentioning

confidence: 99%

Current View of Autonomic Findings During Epileptic Seizures

Baysal-Kıraç¹,

Baykan²

2015

tnd

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“…However, if the paresis evolved gradually over minutes, as is typical for motor auras in migraine, these entities can be differentiated. Moreover, fever is also sometimes seen in the post-epileptic state (34). Although EEGs were frequently performed in our family, abnormalities possibly suggesting epilepsy were found in only one patient (III-28).…”

Section: Discussionmentioning

confidence: 99%

Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation

et al. 2016

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Background Familial hemiplegic migraine (FHM) is a rare monogenic migraine subtype characterised by attacks associated with transient motor weakness. Clinical information is mainly based on reports of small families with only short follow-up. Here, we document a prospective 15-year follow-up of an extended family with FHM type 2. Patients and methods After diagnosing FHM in a patient with severe attacks associated with coma and fever, we identified eight more family members with FHM and one with possible FHM. All family members were prospectively followed for 15 years. In total 13 clinically affected and 21 clinically non-affected family members were genetically tested and repeatedly investigated. Results A novel p.Arg348Pro ATP1A2 mutation was found in 14 family members: 12 with clinical FHM, one with psychomotor retardation and possible FHM, and one without FHM features. In 9/12 (75%) family members with genetically confirmed FHM, attacks were severe, long-lasting, and often associated with impaired consciousness and fever. Such attacks were frequently misdiagnosed and treated as viral meningitis or stroke. Epilepsy was reported in three family members with FHM and in the one with psychomotor retardation and possible FHM. Ataxia was not observed. Conclusion FHM should be considered in patients with recurrent coma and fever.

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