Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

Borgio, João Guilherme Fiorani; Baldaçara, Leonardo; Moraes, Walter André dos Santos; Lacerda, Acioly L.T.; Montaño, Maria Beatriz Marcondes Macedo; Jackowski, Andrea Parolin; Tufik, Sérgio; Ramos, Luiz Roberto; Bressan, Rodrigo A.

doi:10.1590/s0004-282x2012001100003

Cited by 9 publications

(4 citation statements)

References 21 publications

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“…In this study, a decrease in visual memory and volume loss of the right hippocampus were observed together, but no association was found between SNSB memory task performance and hippocampal volume. Loss of the right hippocampal volume with visual memory impairment, as seen in the converter group, could be an important predictor of disease progression from amnestic MCI to dementia 21. This suggests that the right hippocampus is more involved in overall visual memory processes, including encoding, retention, and recognition, than in any specific part of visual memory 19,22,23.…”

Section: Discussionmentioning

confidence: 95%

“…Loss of the right hippocampal volume with visual memory impairment, as seen in the converter group, could be an important predictor of disease progression from amnestic MCI to dementia. 21 This suggests that the right hippocampus is more involved in overall visual memory processes, including encoding, retention, and recognition, than in any specific part of visual memory. 19,22,23 Therefore, even in the MCI state, dysfunction in visual memory with right hippocampal atrophy can be a marker for conversion to dementia.…”

Section: Discussionmentioning

confidence: 99%

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Early Impairment in the Ventral Visual Pathway Can Predict Conversion to Dementia in Patients With Amyloid-negative Amnestic Mild Cognitive Impairment

Kim

Cheong²,

et al. 2021

Alzheimer Disease &Amp; Associated Disorders

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Background: Around 15% to 20% of patients with clinically probable Alzheimer disease have been found to have no significant Alzheimer pathology on amyloid positron emission tomography. A previous study showed that conversion to dementia from amyloid-negative mild cognitive impairment (MCI) was observed in up to 11% of patients, drawing attention to this condition. Object: We gathered the detailed neuropsychological and neuroimaging data of this population to elucidate factors for conversion to dementia from amyloid-negative amnestic MCI. Methods: This study was a single-institutional, retrospective cohort study of amyloid-negative MCI patients over age 50 with at least 36 months of follow-up. All subjects underwent detailed neuropsychological testing, 3 tesla brain magnetic resonance imaging), and fluorine-18(18F)-florbetaben amyloid positron emission tomography scans. Results: During the follow-up period, 39 of 107 (36.4%) patients converted to dementia from amnestic MCI. The converter group had more severe impairment in all visual memory tasks. The volumetric analysis revealed that the converter group had significantly reduced total hippocampal volume on the right side, gray matter volume in the right lateral temporal, lingual gyri, and occipital pole. Conclusion: Our study showed that reduced gray matter volume related to visual memory processing may predict clinical progression in this amyloid-negative MCI population.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Early Impairment in the Ventral Visual Pathway Can Predict Conversion to Dementia in Patients With Amyloid-negative Amnestic Mild Cognitive Impairment

Kim

Cheong²,

et al. 2021

Alzheimer Disease &Amp; Associated Disorders

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“…It has been suggested that CDR may be more sensitive than informant-based assessment in identifying a high risk for white-matter lesions [8] . In addition, one study demonstrated that CDR-SoB might be as efficient as assessment of hippocampal atrophy through neuroimaging in predicting the progression from Mild Cognitive Impairment (MCI) to dementia [9] .…”

Section: Introductionmentioning

confidence: 99%

Subcortical Vascular Cognitive Impairment staged through cdr's functional subsum (cdr-func): Preliminary results from an outpatient sample

et al. 2016

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BackgroundStaging vascular cognitive impairment (VCI) might be useful for sample selection in clinical trials and for guiding clinical decision-making. Clinical dementia rating (CDR) has been applied for staging cognitive impairments of different etiologies, but it may underestimate severity of non-Alzheimer's disease cognitive deficits.MethodsOut of a total of 147 elderly subjects, 23 (mean age: 72.95 ± 7.51 years; 56% female; mean schooling: 9.52 ± 5.11 years) fulfilled clinical and neuroimaging criteria for VCI. Correlations among cognitive and functional status and scores in CDR and its subsums (CDR Sum of Boxes – CDR-SoB - and CDR Functional Subsum – CDR-FUNC) were performed.ResultsBoth CDR-SoB and CDR-FUNC correlated with global cognitive performance, functional status, CLOX 2, working memory and abstraction tests. CDR global score only correlated with functional status.DiscussionCDR-FUNC, as well as CDR-SoB, appear to be better indexes of severity in VCI than CDR global score.

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“…The study carried out by Borgio et al in this issue raises a relevant clinical question, already analyzed by several Brazilian colleagues [5][6][7] . There is the need not only to improve the early diagnosis, but also to develop safe procedures to predict the conversion to dementia in patients with mild cognitive impairment as well.…”

mentioning

confidence: 96%

Predicting dementia or diagnosing early stages of Alzheimer's disease?: how the hippocampal volume and the Clinical Dementia Rating-SB can help early diagnosis

Laks¹

2012

Arq. Neuro-Psiquiatr.

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Hippocampal volume and CDR-SB can predict conversion to dementia in MCI patients

Cited by 9 publications

References 21 publications

Early Impairment in the Ventral Visual Pathway Can Predict Conversion to Dementia in Patients With Amyloid-negative Amnestic Mild Cognitive Impairment

Early Impairment in the Ventral Visual Pathway Can Predict Conversion to Dementia in Patients With Amyloid-negative Amnestic Mild Cognitive Impairment

Subcortical Vascular Cognitive Impairment staged through cdr's functional subsum (cdr-func): Preliminary results from an outpatient sample

Predicting dementia or diagnosing early stages of Alzheimer's disease?: how the hippocampal volume and the Clinical Dementia Rating-SB can help early diagnosis

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