Cerebrospinal fluid oligoclonal IgG bands in multiple sclerosis: what does it mean?

Puccioni-Sohler, Márzia

doi:10.1590/s0004-282x2012000800001

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…According to Katrak et al, patients with HIV infection are more likely to develop cerebral atrophy, infarcts and granuloma compared to the HIV negative patients (9). Besides, the presence of CSF oligoclonal IgG bands is not specific for multiple sclerosis; it is found in 85% of patients who have defined multiple sclerosis, but can also be seen in cranial infectious disease (10). This proved a fact that it is not always a straightforward approach for the diagnosis of TBM.…”

Section: Discussionmentioning

confidence: 99%

A Case of Tuberculous Cerebrospinal Meningitis with Atypical Multiple Lesions

Zhang

2015

West Indian Med J

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Section: Discussionmentioning

confidence: 99%

A Case of Tuberculous Cerebrospinal Meningitis with Atypical Multiple Lesions

Zhang

2015

West Indian Med J

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Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis

et al. 2015

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In previous studies of human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), areas of slow blood flow in the spinal cord were related to pathological changes. While the pathological changes in the brain are milder than those in the spinal cord, they are also more significant in sites with slow blood flow. In this study, we investigated brain glucose metabolism in slow blood flow areas using fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET). Clinical features and brain (18)F-FDG-PET parameters were analyzed in six patients with HAM/TSP. For comparison of PET data, eight healthy volunteers were enrolled as normal controls (NLs). Glucose metabolism in the watershed areas of the middle and posterior cerebral arteries, as compared with that in the occipital lobes as a control, was significantly lower in HAM/TSP patients than in NLs. This result confirmed the relationship between slow blood flow areas and hypometabolism in HAM/TSP, and is consistent with previous findings that pathological changes are accentuated in sites with slow blood flow.

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Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

et al. 2014

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In tropical spastic paraparesis, spinal cord atrophy is a well-known finding in magnetic resonance imaging. But in contrast to histological reports, focal lesions of the spinal cord have only been described in imaging reports in exceptional acute cases. Here, we looked for such focal lesions and for alterations of diffusion tensor imaging parameters of the long fibre tracts in the usual case of a long-standing and slowly progressive disease. We examined 10 symptomatic patients, 11 seropositive, but asymptomatic human T-lymphotrophic virus type 1 carriers and 18 seronegative volunteers as controls. Sagittal and transversal T2-weighted images were visually assessed for atrophy and focal cord lesions. The spinal cord cross-sectional areas and the segmental cord volumes were measured at all levels. High-resolution diffusion tensor imaging was performed in sagittal planes from the bregma down to the cervical spine. For tractography and calculation of fractional anisotropy and mean diffusivity, we used manufacturer-provided software. Two-thirds of patients showed focal lesions affecting the antero-lateral columns and in two cases also the dorsal columns. Compared to carriers and volunteers, patients presented a significant spinal cord atrophy and a reduction of fractional anisotropy (p < 0.05), correlating more to duration of symptoms than to clinical impairment. Because our carriers did not show a significant atrophy, focal lesions or a change of diffusion tensor imaging parameters, we need further long-term studies to see if these parameters at some stage may be used as early indicators of spinal cord affection in virus carriers.

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Cerebrospinal fluid oligoclonal IgG bands in multiple sclerosis: what does it mean?

Cited by 5 publications

References 8 publications

A Case of Tuberculous Cerebrospinal Meningitis with Atypical Multiple Lesions

A Case of Tuberculous Cerebrospinal Meningitis with Atypical Multiple Lesions

Hypometabolism of watershed areas of the brain in HTLV-1-associated myelopathy/tropical spastic paraparesis

Atrophy, focal spinal cord lesions and alterations of diffusion tensor imaging (DTI) parameters in asymptomatic virus carriers and patients suffering from human T-lymphotrophic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

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