Management of desmoid-type fibromatosis involving peripheral nerves

Siqueira, Mário G.; Tavares, Paulo L.; Martins, Roberto S.; Heise, Carlos Otto; Foroni, Luciano; Bordalo-Rodrigues, Marcelo; Falzoni, Roberto

doi:10.1590/s0004-282x2012000700008

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Although lacking metastatic potential, it typically widely infiltrates into soft tissues, frequently encompassing neurovascular structures. [3][4][5]12,[23][24][25]27,[29][30][31][32] It can compress, encompass, or invade nerves or track along them, making it difficult to achieve complete excision without compromising nerve function. Recurrence typically happens locally but can occur at distant sites as well, either synchronously or metachronously.…”

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confidence: 99%

Recurrent desmoid-type fibromatosis associated with underlying neuromuscular choristoma

Stone

Prasad

Laumonerie

et al. 2019

Journal of Neurosurgery

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OBJECTIVE Desmoid-type fibromatosis (DTF) presents a therapeutic dilemma. While lacking metastatic potential, it is a locally aggressive tumor with a strong propensity for occurrence near nerve(s) and recurrence following resection. In this study, the authors introduce the association of an occult neuromuscular choristoma (NMC) identified in patients with DTF. METHODS After experiencing a case of DTF found to have an occult NMC, the authors performed a retrospective database review of all other cases of biopsy-proven DTF involving the extremities or limb girdles in patients with available MRI data. Two musculoskeletal radiologists with expertise in peripheral nerve imaging reviewed the MRI studies of the eligible cases for evidence of previously unrecognized NMC. RESULTS The initial case of a patient with an occult sciatic NMC is described. The database review yielded 40 patients with DTF-18 (45%) in the upper limb and 22 (55%) in the lower limb. Two cases (5%) had MRI findings of NMC associated with the DTF, one in the proximal sciatic nerve and the other in the proximal tibial and sural nerves. CONCLUSIONS The coexistence of NMC may be under-recognized in a subset of patients with extremity DTF. This finding poses implications for DTF treatment and the likelihood of recurrence after resection or biopsy. Further study may reveal crucial links between the pathogenesis of NMC and DTF and offer novel therapeutic strategies.

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confidence: 99%

Recurrent desmoid-type fibromatosis associated with underlying neuromuscular choristoma

Stone

Prasad

Laumonerie

et al. 2019

Journal of Neurosurgery

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“…With an incidence of approximately three to four cases per million, desmoids comprise only 3% of all soft-tissue tumors [6]. The typical site of a desmoid is the abdominal wall, although it sometimes occurs intra-abdominally and involves the bowel and mesentery [7].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Extra-abdominal Desmoid-type Fibromatosis Arising from the Popliteal Fossa

Jain

Das

Gantaguru

et al. 2018

Cureus

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Desmoids are rare soft-tissue tumors of the abdominal wall that may sporadically occur extra-abdominally. It manifests as clonal fibroblastic proliferation with an infiltrative tendency and capacity to recur without metastasizing. An adolescent male presented with a gradually increasing globular, non-tender, firm, non-pulsatile swelling (8 × 5 × 3 cm3) in the left popliteal fossa that had been present for five months. Following thorough investigation with imaging and Tru-cut biopsy, finally, an excisional biopsy was done. Histopathological examination confirmed a desmoid tumor, and the patient received adjuvant radiotherapy. At the one-year postoperative follow-up, there was no recurrence; the patient had been explained the prognosis. This case highlights a rare site of an extra-abdominal desmoid but with classical clinical presentation, imaging, intraoperative, and histopathological findings. Awareness and knowledge of this entity are of paramount importance for clinical practitioners.

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“…We found cases involving upper extremity nerves [27,59], thoracic roots [55] and lower extremity nerves [27].…”

Section: Peripheral Nerve Involvementmentioning

confidence: 91%

“…Next, sometimes a neurosurgical approach is needed when primary head and neck DTs affect the skull base and secondarily grow intracranially [64]. Furthermore, DTs can compromise the brachial or lumbosacral plexus [13], peripheral nerves [59], or the spine and/or spinal cord [55]. Finally, a few authors reported on DTs arising in neurosurgical scars [26].…”

Section: Introductionmentioning

confidence: 99%