Long-term, low-dose immunosuppression for myasthenia does not affect collateral, asymptomatic sclerosing cholangitis

Finsterer, Josef; Höflich, Sonja

doi:10.1590/s0004-282x2012000200019

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…Only one case of a myasthenia associated to a sclerosing cholangitis was published [10]. The practice of hepatic tests are compulsory during the follow up of a myasthenia in order to detect an au-toimmune hepatopathy; since except many no specific signs as asthenia, arthralgia, myalgia, there are any clinical manifestation that orientates to this diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Mahfoudhi¹,

Mamlouk²,

Turki³

et al. 2015

OJCD

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The myasthenia gravis is an autoimmune disease which can be associated frequently with a thymoma and also with autoimmune pathologies. We report the case of a 64-year-old man affected an overlap syndrome corresponding to the association of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). He also presented concomitant myasthenia gravis and thymoma. The physical examination notes only a disturbed voice. The liver tests showed: alkaline phosphatase 600 U/l, alanine aminotransferase 1280 U/l, and aspartate aminotransferase 985 U/l. Viral serologies of hepatitis were all negative, as well as antinuclear, antimitochondrial and antismooth muscle antibodies. The diagnosis of an overlap syndrome was posed according to the biological and hepatic histhological results. An associated myasthenia was confirmed by the results of the EMG and the positivity of the anti-acetylcholine receptor antibody. A chest CT revealed a thymoma. The treatment consisted of ursodeoxycholic acid, prednisone, azathioprine and pyridostigmine. And the patient improved his voice and the liver function. Thymectomy was practiced without incidents.

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Section: Discussionmentioning

confidence: 99%

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Mahfoudhi¹,

Mamlouk²,

Turki³

et al. 2015

OJCD

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Overlap Syndrome and Myasthenia Gravis: An Uncommon Association With Unusual Features

Ray

2019

ACG Case Rep J

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The author presents a rare case of overlap syndrome associated with myasthenia gravis in the absence of acetylcholine receptor antibody and thymoma. Various liver autoantibodies developed at different times later in the disease course and myasthenia occurred 5 years after the diagnosis of liver disease. The importance of repeating antibody panel later in the disease course for proper diagnosis and timely treatment is highlighted. The exact mechanism of the development of myasthenia gravis in autoimmune liver disease also needs investigation for the possibility of new drug development that might be beneficial to both.

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Long-term, low-dose immunosuppression for myasthenia does not affect collateral, asymptomatic sclerosing cholangitis

Cited by 2 publications

References 5 publications

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Autoimmune Hepatitis-Primary Biliary Cirrhosis: Overlap Syndrome Concomitant with Unexpected Myasthenia and Thymoma

Overlap Syndrome and Myasthenia Gravis: An Uncommon Association With Unusual Features

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