Metabolic syndrome and dementia associated with Parkinson's disease: impact of age and hypertension

Abstract

OBJECTIVE: To determine correlations between age and metabolic disorders in Parkinson's disease (PD) patients. METHODS: This observational cross-sectional study included brief tests for dementia and the Mattis test. Signals of metabolic syndrome were evaluated. RESULTS: There was no significant effect from the presence of hypertension (OR=2.36 for patients under 65 years old and OR=0.64 for patients over 65), diabetes or hypercholesterolemia regarding occurrences of dementia associated with PD (24% of the patients). The study demonstrated that each year of age increased the estimated risk of dementia in PD patients by 9% (OR=1.09; 95%CI: 1.01-1.17). CONCLUSION: There was no evidence to correlate the presence of metabolic syndrome with the risk of dementia that was associated with PD. The study confirmed that dementia in PD is age dependent and not related to disease duration.

Reduced vascular risk factors in Parkinson's disease dementia and dementia with Lewy bodies compared to Alzheimer's disease

“…Whether or not systemic or brain vascular diseases contribute to the progression of PD patients to the development of cognitive dysfunction or dementia is still controversial. Some studies of the association of VRFs with PD revealed no significantly contribution of VRFs to the risk of PD or to the progression of PD to PDD (Haugarvoll et al., ; Schelp et al., ; Simon et al., ; Sławek et al., , ). The others provided positive conclusion (Papapetropoulos et al., , ; Rektor et al., ).…”

“…Schelp et al. studied the relationship between metabolic disorders and progression of dementia in PD and revealed that dementia in PD is age‐dependent and not related to disease duration (Schelp et al., ). Rektor et al.…”

“…However, studies on the association between VRFs and Lewy body dementia (LBD) are limited. Previous studies had put more emphasis on the association of VRFs mainly with Parkinson's disease (PD) patients regardless of whether or not they developed dementia, and the results were controversial (Haugarvoll, Aarsland, Wentzel‐Larsen, & Larsen, ; Papapetropoulos, Villar, & Mash, ; Papapetropoulos et al., ; Rektor et al., ; Schelp, Mendes‐Chiloff, Bazan, Paduan, & Pioltini, ; Scigliano et al., ; Simon, Chen, Schwarzschild, & Ascherio, ; Sławek et al., , ; Toledo et al., ). Reduced risk factors for vascular disorders were found in patients with PD (Scigliano et al., ) or with α‐synucleinopathy (Toledo et al., ).…”

“…Reduced risk factors for vascular disorders were found in patients with PD (Scigliano et al, 2006) or with α-synucleinopathy (Toledo et al, 2013). Some studies suggested that PD risk was not significantly related to history of hypertension, hypercholesterolemia, or diabetes (Haugarvoll et al, 2005;Schelp et al, 2012;Simon et al, 2007;Sławek et al, 2008Sławek et al, , 2010, and other studies showed positive contribution (Papapetropoulos et al, 2004(Papapetropoulos et al, , 2006Rektor et al, 2009). Although dementia with Lewy bodies (DLB) is the second most common degenerative dementia (Karantzoulis & Galvin, 2013;McKeith et al, 1996), the study of VRFs associated with DLB is scarce (Boot et al, 2013).…”

Diagnóstico e manejo da demência da doença de Parkinson e demência com corpos de Lewy: recomendações do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

“…Na DDP, o comprometimento cognitivo frequentemente se correlaciona com estágio da doença mais avançado, idade avançada, baixa escolaridade e depressão, além de pior qualidade de vida 15,17,28 . Não há comprovada correlação entre fatores de risco cardiovascular e DDP 29 .…”