Hyperintense basal ganglia on MR imaging in hematopoietic stem cell transplantation recipient

Abstract

A 13-year-old boy presented seizures on day +37 after allogenic hematopoietic stem cell transplantation (HSCT) for Fanconi anemia. After HSCT this patient had received total parental nutrition (TPN) for 21 days. Neurological examination was normal. A MRI of the brain ( Figure A-B) showed symmetric areas of hyperintensity in the basal ganglia. Serum manganese (Mn) was 7.7 μg/L (reference value <3.3 μg/L).Basal ganglia Mn deposition, associated to elevated blood Mn levels, has been described in children receiving long-term TPN 1-3 . HIPERINTENSIDADE NOS GÂNGLIOS DA BASE EM RESSONÂNCIA MAGNÉTICA DO CRÂNIO EM PACIENTE PÓS-TRANSPLANTE DE CÉLULAS TRONCO HEMATOPOIÉTICA.Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba PR, Brazil: 1 Neurology; 2 Bone Marrow Transplantation Services.