Correlations between motor and sensory functions in upper limb chronic hemiparetics after stroke

Scalha, Thais Botossi; Miyasaki, Erica; Lima, Núbia Maria Freire Vieira; Borges, Guilherme

doi:10.1590/s0004-282x2011000500010

Cited by 46 publications

(42 citation statements)

References 23 publications

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“…PROG at all three doses led to significant improvement in outcome measures, but again, the P8 group had the best performance overall. A number of studies have reported that somatosensory stimulation results in improved motor functions and motor cortex plasticity in stroke patients (Ward and Cohen 2004; Scalha et al 2011). We found that PROG reduced somatosensory neglect, which in turn led to better motor recovery in the sub-acute post-stroke period.…”

Section: Discussionmentioning

confidence: 99%

Progesterone in transient ischemic stroke: a dose–response study

et al. 2014

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Rationale Previous studies demonstrate the neuroprotective effects of progesterone in numerous animal injury models, but a systematic dose–response study in a transient ischemic stroke model is lacking. Objectives We investigated the effects of progesterone at different doses on post-stroke brain infarction and functional deficits in middle-aged rats. Methods Cerebral ischemia was induced in 13-month-old male Sprague–Dawley rats by right middle cerebral artery occlusion for 2 h followed by reperfusion. Rats received intraperitoneal injections of 8, 16, or 32 mg/kg of progesterone (P8, P16, P32) or vehicle at 2 h post-occlusion followed by subcutaneous injections at 6 h and every 24 h post-injury for 7 days. Functional recovery was evaluated at intervals over 22 days using motor, sensory, and cognitive tests. Infarct size was evaluated at 22 days post-stroke. Results Repeated-measures ANOVA showed significant group effects on grip strength, rotarod, and sensory neglect. All progesterone-treated groups had improved (p<0.05) spatial memory performance. The P8 and P16 groups showed maximum improvement in long-term memory compared to vehicle. Significant (p<0.05) gait impairments were observed in the vehicle group compared to shams. Animals receiving the P8 dose showed maximum gait improvement compared to vehicle. Post hoc analysis revealed that the P8 and P16 groups showed significant attenuation in infarct volume compared to vehicle. Animals receiving the P32 dose did not show any effect on infarct volume. Conclusions Although all doses were somewhat effective, progesterone given at 8 mg/kg led to the most consistent improvements across a panel of behavioral/functional tests and reduced the severity of ischemic infarct injury.

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Section: Discussionmentioning

confidence: 99%

Progesterone in transient ischemic stroke: a dose–response study

et al. 2014

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“…Recently, eye movements have been shown in stroke investigations to be a sensitive biomarker for cognitive and motor recovery (149, 150). Additionally, poststroke patients display unique pathophysiologic phenotypes that may include tactile deficits (151–153), proprioceptive losses (154, 155), hemiparesis and related motor synergies (156–158), and spasticity (159–161), which would suggest that these new sensory and motor “states” postinjury create new relationships between receptor and effector, requiring the need for re-integration (162–164). …”

Section: Impairment Of the Visuomotor Systemmentioning

confidence: 99%

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

et al. 2017

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Acute and chronic disease processes that lead to cerebral injury can often be clinically challenging diagnostically, prognostically, and therapeutically. Neurodegenerative processes are one such elusive diagnostic group, given their often diffuse and indolent nature, creating difficulties in pinpointing specific structural abnormalities that relate to functional limitations. A number of studies in recent years have focused on eye–hand coordination (EHC) in the setting of acquired brain injury (ABI), highlighting the important set of interconnected functions of the eye and hand and their relevance in neurological conditions. These experiments, which have concentrated on focal lesion-based models, have significantly improved our understanding of neurophysiology and underscored the sensitivity of biomarkers in acute and chronic neurological disease processes, especially when such biomarkers are combined synergistically. To better understand EHC and its connection with ABI, there is a need to clarify its definition and to delineate its neuroanatomical and computational underpinnings. Successful EHC relies on the complex feedback- and prediction-mediated relationship between the visual, ocular motor, and manual motor systems and takes advantage of finely orchestrated synergies between these systems in both the spatial and temporal domains. Interactions of this type are representative of functional sensorimotor control, and their disruption constitutes one of the most frequent deficits secondary to brain injury. The present review describes the visually mediated planning and control of eye movements, hand movements, and their coordination, with a particular focus on deficits that occur following neurovascular, neurotraumatic, and neurodegenerative conditions. Following this review, we also discuss potential future research directions, highlighting objective EHC as a sensitive biomarker complement within acute and chronic neurological disease processes.

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“…Whereas in MVF, much of the cognitive workload can be offloaded onto the mirror, more mental effort is required in NF-MIT23. Given the fact, that stroke-induced motor impairment seldom comes in isolation, but is typically accompanied by cognitive impairment24, sensibility loss2526 or MI ability impairment27, the question thus is which patients are actually still able to perform MI with their paretic body side2829, and when is a bottom-up motor percept induct more applicable. Whereas in NF-MIT the patient is supported by a neurofeedback signal, which helps to perform the mental act and facilitates imagery-induced motor cortex activation3031, no neurofeedback signal can typically be provided in MVF.…”

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confidence: 99%

Embodied neurofeedback with an anthropomorphic robotic hand

Braun¹,

Emkes²,

Thorne³

et al. 2016

Sci Rep

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Neurofeedback-guided motor imagery training (NF-MIT) has been suggested as a promising therapy for stroke-induced motor impairment. Whereas much NF-MIT research has aimed at signal processing optimization, the type of sensory feedback given to the participant has received less attention. Often the feedback signal is highly abstract and not inherently coupled to the mental act performed. In this study, we asked whether an embodied feedback signal is more efficient for neurofeedback operation than a non-embodiable feedback signal. Inspired by the rubber hand illusion, demonstrating that an artificial hand can be incorporated into one’s own body scheme, we used an anthropomorphic robotic hand to visually guide the participants’ motor imagery act and to deliver neurofeedback. Using two experimental manipulations, we investigated how a participant’s neurofeedback performance and subjective experience were influenced by the embodiability of the robotic hand, and by the neurofeedback signal’s validity. As pertains to embodiment, we found a promoting effect of robotic-hand embodiment in subjective, behavioral, electrophysiological and electrodermal measures. Regarding neurofeedback signal validity, we found some differences between real and sham neurofeedback in terms of subjective and electrodermal measures, but not in terms of behavioral and electrophysiological measures. This study motivates the further development of embodied feedback signals for NF-MIT.

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Correlations between motor and sensory functions in upper limb chronic hemiparetics after stroke

Cited by 46 publications

References 23 publications

Progesterone in transient ischemic stroke: a dose–response study

Progesterone in transient ischemic stroke: a dose–response study

The Intersection between Ocular and Manual Motor Control: Eye–Hand Coordination in Acquired Brain Injury

Embodied neurofeedback with an anthropomorphic robotic hand

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