Different cognitive profiles of Brazilian patients with relapsing-remitting and primary progressive multiple sclerosis

Rodrigues, David Henrique; Paes, Renata Alves; Vasconcelos, Cláudia Cristina Ferreira; Landeira-Fernández, J.; Alvarenga, Maria Papais

doi:10.1590/s0004-282x2011000500004

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…In fact, most studies from our systematic literature research report symptoms only at disease onset, which mainly includes weakness of lower limbs and ataxia, vision impairment in up to 41% and cognitive impairment in up to 6% [5], [20], [27], [31]. Interestingly, in a Brazilian cohort cognitive impairment was found in 73% of PPMS patients compared to 46% in a RRMS control group [32]. Other data show a decrease in cognitive function of PPMS patients through time [33], [34].…”

Section: Discussionmentioning

confidence: 97%

Validating Predictors of Disease Progression in a Large Cohort of Primary-Progressive Multiple Sclerosis Based on a Systematic Literature Review

et al. 2014

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BackgroundNew agents with neuroprotective or neuroregenerative potential might be explored in primary-progressive Multiple Sclerosis (PPMS) - the MS disease course with leading neurodegenerative pathology. Identification of patients with a high short-term risk for progression may minimize study duration and sample size. Cohort studies reported several variables as predictors of EDSS disability progression but findings were partially contradictory.ObjectiveTo analyse the impact of published predictors on EDSS disease progression in a large cohort of PPMS patients.MethodsA systematic literature research was performed to identify predictors for disease progression in PPMS. Individual case data from the Sylvia Lawry Centre (SLC) and the Hamburg MS patient database (HAPIMS) was pooled for a retrospective validation of these predictors on the annualized EDSS change.ResultsThe systematic literature analysis revealed heterogeneous data from 3 prospective and 5 retrospective natural history cohort studies. Age at onset, gender, type of first symptoms and early EDSS changes were available for validation. Our pooled cohort of 597 PPMS patients (54% female) had a mean follow-up of 4.4 years and mean change of EDSS of 0.35 per year based on 2503 EDSS assessments. There was no significant association between the investigated variables and the EDSS-change.ConclusionNone of the analysed variables were predictive for the disease progression measured by the annualized EDSS change. Whether PPMS is still unpredictable or our results may be due to limitations of cohort assessments or selection of predictors cannot be answered. Large systematic prospective studies with new endpoints are needed.

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Section: Discussionmentioning

confidence: 97%

Validating Predictors of Disease Progression in a Large Cohort of Primary-Progressive Multiple Sclerosis Based on a Systematic Literature Review

et al. 2014

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“…The brief neuropsychological assessment battery applied in the same group of MS patients on a parallel ongoing study was previously used by Paes 13 and Rodrigues et al 14 . This battery focused tests with higher sensitivity and specificity, according to Negreiros et al 15 and Paes et al 16 .…”

Section: Neuropsychological Assessmentmentioning

confidence: 99%

Personality factors in recently diagnosed multiple sclerosis patients: a preliminary investigation with the NEO-FFI scale

Lima

Paes

Alvarenga

2015

Arq. Neuro-Psiquiatr.

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This article describes some prevalent personality dimensions of recently diagnosed multiple sclerosis patients. A sample of 33 female recently diagnosed with relapsing-remitting multiple sclerosis (RRMS) was assessed with the NEO-FFI personality scale. Beck depression (BDI) and anxiety (BAI) scales were also used. No significant levels of anxiety or depression were identified in this group. As for personality factors, conscientiousness was the most common factor found, whereas openness to experience was the least observed. Literature on the relationship between personality and MS is scarce and there are no Brazilian studies on this subject. Some personality traits might complicate or facilitate the experience of living with a chronic, disabling and uncertain neurological condition such as MS.Keywords: multiple sclerosis, personality, NEO-FFI. RESUMOEste artigo descreve alguns traços prevalentes de personalidade em pacientes com esclerose múltipla recém-diagnosticada. Uma amostra de 33 mulheres recentemente diagnosticadas com a forma clínica remitente-recorrente da esclerose múltipla (EMRR) foi avaliada com a escala de personalidade NEO-FFI. As escalas de Beck de depressão e de ansiedade também foram usadas. Não foram identificados níveis significativos de ansiedade ou depressão neste grupo. Em relação aos fatores de personalidade, a conscienciosidade se mostrou como o traço mais prevalente, enquanto a abertura à experiência foi o menos observado nesta amostra. A literatura acerca desta relação esclerose múltipla-personalidade é pouco expressiva e não há estudos brasileiros sobre este tema. Acredita-se que alguns traços de personalidade possam dificultar ou facilitar a experiência de estar vivendo com uma condição neurológica crônica, incapacitante e de curso incerto como a esclerose múltipla.Palavras-chave: esclerose múltipla, personalidade, NEO-FFI.

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“…In addition, there was no significant correlation between BDI and neuropsychological scores, consistent with some studies 45 . In contrast, some authors have shown a significant, but weak, association between depression and cognitive performance in patients with MS 40,48 .…”

Section: Discussionmentioning

confidence: 89%

Cognitive assessment of Brazilian patients with multiple sclerosis: weighing the impact of disability and depressive symptoms

Andrade

Cerqueira

Colodetti

et al. 2022

Dement. neuropsychol.

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Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Cognition is not routinely assessed in patients with MS though they frequently have cognitive complaints or dysfunction. Objective: The aim of this study was to compare the cognitive status of patients with MS with age, sex, and schooling matched controls and to evaluate the potential influence of clinical parameters on cognition. Methods: A total of 35 patients with MS (mean±SD age 37.9 years±11.44, M/F: 12/23) and 33 healthy controls (mean±SD age 38.8 years±12.6, M/F: 12/21) were enrolled in this study. All subjects underwent a structured clinical assessment and the cognitive tools are as follows: Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), Rey Auditory Verbal Learning Test (RAVLT), Digit Span, and Verbal Fluency Tests (letters F, A, and S and animal category). Psychopathology was assessed with the Mini International Neuropsychiatric Interview and the Beck Depression Inventory (BDI). The Expanded Disability Status Scale (EDSS) was used for patients. Results: Patients performed worse than controls in almost all tests, with approximately 70% of patients presenting cognitive impairment. The most affected cognitive domain was episodic memory (45.7%), followed by verbal fluency (42.8%) and information processing speed (22.8%). SDMT was inversely correlated with disease severity, as assessed by the EDSS. Depression did not influence cognitive performance in this cohort. Conclusions: Cognitive dysfunction is common among patients with MS. While motor impairment was associated with information processing speed, depression did not influence cognitive performance.

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Different cognitive profiles of Brazilian patients with relapsing-remitting and primary progressive multiple sclerosis

Cited by 9 publications

References 21 publications

Validating Predictors of Disease Progression in a Large Cohort of Primary-Progressive Multiple Sclerosis Based on a Systematic Literature Review

Validating Predictors of Disease Progression in a Large Cohort of Primary-Progressive Multiple Sclerosis Based on a Systematic Literature Review

Personality factors in recently diagnosed multiple sclerosis patients: a preliminary investigation with the NEO-FFI scale

Cognitive assessment of Brazilian patients with multiple sclerosis: weighing the impact of disability and depressive symptoms

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