Intracerebral amyloidoma: imaging findings might support preoperative diagnosis

Rocha, Antônio José da; Silva, Carlos Jorge da; Leopoldino, Jose Fabio Santos; Andrade, Victor Piana de

doi:10.1590/s0004-282x2011000300033

Cited by 4 publications

(2 citation statements)

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“…Thus, suggesting that surgery may not be needed in the management of CA. Importantly, it was reported that MRI may be sufficient in establishing the diagnosis without the need for brain biopsy 11. Indeed, finding a blood test for systemic amyloidosis will remain a diagnostic challenge 12…”

Section: Discussionmentioning

confidence: 99%

Hiding in plain sight: a brain lesion in a patient with a history of colon and breast cancer

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Hiding in plain sight: a brain lesion in a patient with a history of colon and breast cancer

et al. 2018

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“…[4] [5][6] [18] [25][30] [34] [35] [40][42] [44] [46] [48][49] [51] [52] NA = not available; CT− = native CT; CT+ = post contrast CT; hypo = hypo dense or intense; hyper = hyper dense or intense; Mixte = hypo-hyper-intense; gado = gadolinium; LC = light chain, λLC = Lambda light chain; κ LC = Kappa light chain; TTR = transthyretrin; SAP =; λLC --= Lambda LC negative.and it may show a hypo, hyper-signal or a combination of both on T2-WI. Following gadolinium infusion, whatever the signal type on T1 and T2-WI, the lesion almost enhances except in two cases[4] [7].…”

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confidence: 99%

Brain Amyloidoma: Case Report and Literature Review

Moumouni¹,

Zolo²,

Kpelao³

et al. 2020

OJMN

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Introduction: Primary deposition of amyloid can take several forms including amyloidoma organ restricted among which is brain. Brain amyloidoma can mimic several lesions and offers a diagnostic challenge to the physician. The present work reports an additional case and summarizes the salient characteristics of previously published cases. Case Report: A 61-year-old, woman experienced paroxystic auditory hallucinations followed at times by generalized tonico-clonic seizures. Examination revealed a mild left pyramidal weakness. Head CT scan and MRI revealed a lobular lesion of the right atrium with contrast enhancement. The diagnosis of amyloidoma Lambda light chain (λLC) type was performed by means of a stereotactic biopsy. The patient was treated by 3 cures of high dose methotrexate (15 mg/m 2 ). At 24 months follow up the patient remains stable clinically and biologically. The 2 years follow-up MRI showed the same findings. Conclusion: No guidelines can be suggested for brain amyloidoma treatment; the "wait and see" was the mind-set in the literature. However, a non-tumour like pattern of a cerebral mass developing near the ventricle with a fine, irregular radiating margin enhancement and lack of oedema, and mass effect are important MRI clues for brain amyloidoma diagnosis. The diagnosis is histological after biopsy or excision.

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