Cognitive deficits in multiple sclerosis: a systematic review

Ferreira, Maria Lúcia Brito

doi:10.1590/s0004-282x2010000400029

Cited by 63 publications

(56 citation statements)

References 30 publications

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“…The recent review by Ferreira 14 showed that assessing cognition in MS is a challenge. A large variety of factors that are not specifically related to cognitive dysfunction may influence performance in the tests usually used in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

“…Most neurologists do not have a neuropsychologist available for testing all patients and, therefore, have to screen and select cases for referral, for proper and detailed neuropsychological testing. Ferreira 14 concluded that the absence of uniform recommendations for cognition testing make it difficult to obtain clear evidence of cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

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Paced auditory serial addition test (PASAT): a very difficult test even for individuals with high intellectual capability

Brooks

Giraud

Saleh

et al. 2011

Arq. Neuro-Psiquiatr.

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Objective: To assess the difficulty of paced auditory serial addition test (PASAT) in a population of high intellectual level, under ideal cognitive testing circumstances. Method: One hundred medical students underwent PASAT testing. They had slept well the night before, they had eaten before the assessment, they were not using any drugs that could affect the central nervous system and they did not have depression, anxiety or any chronic disease. Results: The average result from the three-second version of PASAT was 57.5% and, from the two-second version, it was 44.3%. Conclusion: Even under ideal circumstances, PASAT is a very difficult test for the general population. It may not be ideal for neurologists to screen, assess and follow up patients with cognitive function in multiple sclerosis. Key words: multiple sclerosis, PASAT, cognition, test.Teste auditivo compassado de adição seriada (PASAT): um teste muito difícil mesmo para indivíduos com alta capacidade intelectual RESUMO Objetivo: Avaliar a dificuldade do teste auditivo compassado de audição seriada (PASAT) em uma população de alto nível intelectual, sob condições ideais para testes cognitivos. Método: Cem estudantes de medicina se submeteram ao PASAT. Eles haviam dormido bem na noite anterior, tinham comido antes da avaliação, não estavam em uso de qualquer droga que pudesse afetar o sistema nervoso central e não apresentavam depressão, ansiedade ou qualquer doença crônica. Resultados: A média de acertos na versão de três segundos do PASAT foi 57,5% e, para a versão de dois segundos, a média foi 44,3%. Conclusão: Mesmo sob condições ideais, PASAT é um teste muito difícil para a população geral. Talvez ele não seja ideal para que os neurologistas triem, avaliem e façam seguimento da função cognitiva na esclerose múltipla. Palavras-chave: esclerose múltipla, PASAT, cognição, teste. Correspondence Yára Dadalti Fragoso

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Paced auditory serial addition test (PASAT): a very difficult test even for individuals with high intellectual capability

Brooks

Giraud

Saleh

et al. 2011

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…Notwithstanding all the recent scientific progress, the subject of cognitive dysfunction in MS remains open to discussion. For many authors, one of the key points of discussion on this subject is the instrument for cognitive assessment 10 . While a full neuropsychological evaluation is, indisputably the gold standard approach to assessing cognition in MS, few are the groups who can count on a neuropsychologist to perform tests in all patients.…”

mentioning

confidence: 99%

Assessment of cognition using the Rao's Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis

Brooks

Borela²,

Fragoso

2011

Arq. Neuro-Psiquiatr.

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To assess the cognition of patients with multiple sclerosis (MS) using the Rao's Brief Repeatable Battery of Neuropsychological Tests (BRB-N). Method: BRB-N was translated and adapted for control subjects. Subsequently, it was applied to a group of patients with relapsing-remitting (RR) MS. Results: The assessment on the healthy controls (n=47) showed that the correlation between tests on the same cognitive domain was high and that there was a five-factor solution that explained 90% of the total variance. Except for the Word List Generation subset of tests, the performance of patients with RRMS (n=39) was worse than that of the healthy controls. Conclusion: BRB-N is a relatively simple method to assess cognition of patients with MS in the daily clinic. It does not take long to apply and does not require special skills or equipment. Key words: multiple sclerosis, cognition, memory, neuropsychology.Avaliação da cognição usando a Bateria Breve de Testes Neuropsicológicos de Rao para pacientes brasileiros com esclerose múltipla RESUMO Avaliar a cognição de pacientes com esclerose múltipla (EM), utilizando a Bateria Breve de Testes Neuropsicológicos de Rao (BRB-N). Método: BRB-N foi traduzida e adaptada para controles. Subsequentemente, foi aplicada em um grupo de pacientes portadores de EM RR. Resultados: A avaliação de controles saudáveis (n=47) mostrou que a correlação entre os testes de um mesmo domínio cognitivo era alta e que uma solução de fator cinco explicava 90% da variação total. Exceto pela Lista de Palavras, o desempenho dos pacientes com EMRR (n=39) foi pior que aquele dos controles saudáveis. Conclusão: BRB-N é um método relativamente simples de avaliar cognição de pacientes com EM na prática clínica. O teste não requer muito tempo e não necessita de treinamento ou equipamentos especiais. Palavras-Chave: esclerose múltipla, cognição, memória, neuropsicologia.

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“…Depression was diagnosed in 25.7 to 54% patients with MS [8]. It can be caused by primary pathology as well as be the result of patient's reaction to the disease related factors, such as pain, progressing disability, difficult life situation, tiredness and cognitive dysfunctions [5,9].…”

Section: Introductionmentioning

confidence: 99%

Zespół zmęczenia, depresja oraz jakość życia u pacjentów ze stwardnieniem rozsianym

Halicka

Tarasiuk

Szczepański

et al. 2017

PNIN

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Introduction. Multiple sclerosis is a chronic disease of central nervous system of autoimmunological origin, in which next to an increased physical disability, neuropsychological disorders exist, that lead to significant decrease in patients' quality of life. Aim. The aim of the study was the assessment of prevalence of fatigue syndrome and depression in patients with multiple sclerosis and their influence on functioning in physical, cognitive and psychosocial dimension as well as on the quality of life. Materials and Methods. 62 patients (37 females and 25 males) with relapsing-remitting subtype of multiple sclerosis and 15 patients with sciatica (9 females and 6 males) as the reference group were included in the study. Prevalence of fatigue syndrome and depression, as well as patients' quality of life were assessed with use of Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory (BDI) and a standardized instrument for use as a measure of health outcome EQ-5D. Results. Fatigue of moderate intensity was noticed in 45.16% (n=28) of patients with relapsing-remitting subtype of MS, when depression was apparent in 51.61% of patients (n=32), including mild depressive disorders in 33.8% of patients (n=21), moderate in 11.29% of patients and severe in 6.45% (n=4). The obtained results did not reach statistical significance when compared to results obtained in the reference group. Statistically significant dependence between the intensity of depression and influence of fatigue on functioning in psychosocial dimension was mainly observed in the group of patients with multiple sclerosis. Conclusions. Fatigue syndrome and depression occur in significant part of patients with relapsing-remitting subtype of multiple sclerosis, disturbing their functioning in psychosocial dimension and considerably decreasing their quality of life. Increase in fatigue in general dimension has a significantly positive correlation with exacerbation of depression in the group of patients with relapsing-remitting subtype of multiple sclerosis. (JNNN 2017;6(2):81-87)

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Cognitive deficits in multiple sclerosis: a systematic review

Cited by 63 publications

References 30 publications

Paced auditory serial addition test (PASAT): a very difficult test even for individuals with high intellectual capability

Paced auditory serial addition test (PASAT): a very difficult test even for individuals with high intellectual capability

Assessment of cognition using the Rao's Brief Repeatable Battery of Neuropsychological Tests on a group of Brazilian patients with multiple sclerosis

Zespół zmęczenia, depresja oraz jakość życia u pacjentów ze stwardnieniem rozsianym

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