Alterations on monoamines concentration in rat hippocampus produced by lipoic acid

Abstract

The purposes of the present study were to verify monoamines (dopamine (DA), norepinephrine (NE), serotonin (5-HT)), and their metabolites (3,4-hydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA)) contents in rat hippocampus after lipoic acid (LA) administration. Wistar rats were treated with 0.9% saline (i.p., control group) and LA (10, 20 or 30 mg/kg, i.p., LA10, LA20 and LA30 groups, respectively). After the treatments all groups were observed for 24 h. The NE and DA levels were increased only in 20 mg/kg dose of LA in rat hippocampus. Serotonin content and in their metabolite 5-HIAA levels was decreased in same dose of LA. On the other hand, in DOPAC and HVA levels did not show any significant change. The alterations in hippocampal monoamines can be suggested as a possible of brain mechanism of action from this antioxidant. The outcome of the study may have therapeutic implications in the treatment of neurodegenerative diseases.

Behavioral and neurochemical effects of alpha lipoic acid associated with omega-3 in tardive dyskinesia induced by chronic haloperidol in rats

“…This improves motor due to the antioxidant D r a f t effect of these substances, reflecting on monoamines levels. The LA has the capacity to alter the levels of monoamines and their metabolites by stimulating the synthesis, release in the synaptic cleft and reduced metabolism of these neurotransmitters thereby increasing its availability in the CNS (Chang et al 2009;Santos et al 2010).…”

Behavioral and Neurochemical Effects of Alpha-Lipoic Acid in the Model of Parkinson’s Disease Induced by Unilateral Stereotaxic Injection of 6-Ohda in Rat

“…The α -lipoic acid is considered one of the most potent endogenous defense systems to combat the formation of reactive oxygen and nitrogen species, besides promoting the renewal of other antioxidants such as vitamin E, C, A, and coenzyme Q10 and reduced GSH, as well as act as a metal chelator [60–62]. …”

“…Another important factor that classifies α -lipoic acid as a universal antioxidant is that it acts both in aqueous and greasy once it is amphipathic and may promote its antioxidant effect in the cytosol, in plasma membranes, in plasma and in lipoproteins [62, 63]. …”

Effects of alpha‐lipoic acid in an animal model of mania induced by d‐amphetamine

“…It is important to state that the DRD2 found in subcortical structures are the most important receptors related to AMPH‐induced hyperlocomotion (60) and are also altered in BD patients (61). In fact, previous research inferred that ALA may influence DA levels (62). The present findings showed that ALA diminished AMPH‐induced hyperlocomotion in both reversal and prevention paradigms.…”