Epidemiologic pattern of patients with neurocysticercosis diagnosed by computed tomography in Curitiba, Brazil

Grazziotin, Ana Laura; Fontalvo, Mariana Campos; Santos, Marilis Beckert Feijó; Monego, Fernanda; Grazziotin, Ana Line; Kolinski, Victor Hugo Zanini; Bordignon, Rodrigo Henrique; Biondo, Alexander Welker; Antoniuk, Affonso

doi:10.1590/s0004-282x2010000200022

“…The relationship between sex and NCC infection risk is controversial. Some studies showed a higher frequency of the disease in males (Chimelli et al, 1998;Chagas et al, 2003;Lino-Junior et al, 2007;Almeida and Torres, 2011), while others showed a higher prevalence of NCC in females (Pfuetzenreiter and Avila-Pires, 1999;Mendes et al, 2005;Benedeti et al, 2007;Grazziotin et al, 2010;Coral-Almeida et al, 2015). A previous literature review on NCC epidemiology in Brazil showed a higher prevalence of NCC among males, with more frequent involvement of severe manifestations in female patients (Agapejev, 2003(Agapejev, , 2011.…”

Section: Discussionmentioning

confidence: 99%

“…Gender-specific healthcare seeking behaviour may also play a role. The more frequent occurrence of clinical manifestations in women would lead them to seek medical assistance more frequently and, consequently, to carry out more diagnostic testing than men (Pfuetzenreiter and Avila-Pires, 1999;Grazziotin et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

Martins-Melo

¹

,

Ramos

²

,

Cavalcanti

³

et al. 2016

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Neurocysticercosis (NCC) is an important cause of severe neurological disease mainly in low- and middle-income countries, but data on NCC mortality from endemic areas are scarce. Here we analysed the epidemiological patterns of NCC-related mortality in Brazil. We included all deaths recorded in Brazil between 2000 and 2011, in which NCC was mentioned on death certificates, either as underlying or as associated cause of death. NCC was identified in 1829/12,491,280 deaths (0.015%), 1130 (61.8%) as underlying cause, and 699 (38.2%) as associated cause. Overall age-adjusted mortality rate for the period was 0.97 deaths/1,000,000 inhabitants (95% confidence interval [CI]: 0.83-1.12). The highest NCC-related mortality rates were found in males, elderly, white race/colour and residents in endemic states/regions. Age-adjusted mortality rates at national level decreased significantly over time (annual percent change [APC]: -4.7; 95% CI: -6.0 to -3.3), with a decrease in the Southeast, South and Central-West regions, and a non-significant increasing trend in the North and Northeast regions. We identified spatial and spatiotemporal high-risk mortality clusters located mainly in NCC-endemic areas. Conditions related to the nervous system were the most commonly associated causes of death when NCC was mentioned as an underlying cause, and HIV/AIDS was the main underlying cause when NCC was an associated cause. NCC is a neglected and preventable cause of severe neurologic disease and death with high public health impact in Brazil. There is a clear need to strengthen nationwide epidemiological surveillance and control for the taeniasis/cysticercosis complex.

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Neurocysticercosis—Retrospective Study of Autopsy Reports, a 17-Year Experience

Almeida

¹

,

Torres

²

2011

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Neurocysticercosis (NCC) is a common central nervous system (CNS) infection caused by Taenia solium metacestodes. The objective of this study is to describe the incidence of cysticercosis diagnosed at autopsies and describe the epidemiological and clinical characteristics of NCC. Retrospective study analyzing 6,500 reports of autopsies between 1977 and 1994 from a school hospital in Curitiba, PR, southern of Brazil. The following data was obtained, age, gender, site of cysticercosis, NCC as cause of death. The diagnosis of cysticercosis was established in 52 (0.8%) autopsies. From 1977 to 1987 (0.7%) and from 1988 to 1994 (1.1%). In the autopsies with cysticercosis 75% were male; age (mean ± SD) was 43 ± 20. NCC was present in 96% of cases, and seizures was the most frequent clinical manifestation. Asymptomatic cases in 54%. These data classify our area as hiperendemic, according with OMS criteria. The present study reinforces the necessity to develop adequate control programs.

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Reprint of “Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death”

Martins-Melo

¹

,

Ramos

²

,

Cavalcanti

³

et al. 2017

View full text Add to dashboard Cite

Neurocysticercosis (NCC) is an important cause of severe neurological disease mainly in low- and middle-income countries, but data on NCC mortality from endemic areas are scarce. Here we analysed the epidemiological patterns of NCC-related mortality in Brazil. We included all deaths recorded in Brazil between 2000 and 2011, in which NCC was mentioned on death certificates, either as underlying or as associated cause of death. NCC was identified in 1829/12,491,280 deaths (0.015%), 1130 (61.8%) as underlying cause, and 699 (38.2%) as associated cause. Overall age-adjusted mortality rate for the period was 0.97 deaths/1,000,000 inhabitants (95% confidence interval [CI]: 0.83-1.12). The highest NCC-related mortality rates were found in males, elderly, white race/colour and residents in endemic states/regions. Age-adjusted mortality rates at national level decreased significantly over time (annual percent change [APC]: -4.7; 95% CI: -6.0 to -3.3), with a decrease in the Southeast, South and Central-West regions, and a non-significant increasing trend in the North and Northeast regions. We identified spatial and spatiotemporal high-risk mortality clusters located mainly in NCC-endemic areas. Conditions related to the nervous system were the most commonly associated causes of death when NCC was mentioned as an underlying cause, and HIV/AIDS was the main underlying cause when NCC was an associated cause. NCC is a neglected and preventable cause of severe neurologic disease and death with high public health impact in Brazil. There is a clear need to strengthen nationwide epidemiological surveillance and control for the taeniasis/cysticercosis complex.

show abstract

Epidemiologic pattern of patients with neurocysticercosis diagnosed by computed tomography in Curitiba, Brazil

Cited by 8 publications

References 9 publications

Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death

Neurocysticercosis—Retrospective Study of Autopsy Reports, a 17-Year Experience

Reprint of “Neurocysticercosis-related mortality in Brazil, 2000–2011: Epidemiology of a neglected neurologic cause of death”

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