Infantile autism and 47,XYY karyotype

Kuczynski, Evelyn; Bertola, Débora Romeo; Castro, Cláudia Irene Emílio de; Koiffmann, Célia Priszkulnik; Kim, Chong

doi:10.1590/s0004-282x2009000400032

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Compared to X chromosome, the Y chromosome abnormalities are often less studied due to its complex and repetitive DNA sequence structure, which makes hard to detect using conventional genetic technologies. Nevertheless, several early studies showed that child carries XYY developed infantile ASD [52–54]. A study of 95 subjects with XXYY (age 1-55 years) demonstrated 92% language delay, 72% with ADHD, 28% with ASD, 47% with mood disorders in the individuals with XXYY [55].…”

Section: Sex Chromosome Abnormalities In Psychiatric Diseasesmentioning

confidence: 99%

Sex chromosome abnormalities and psychiatric diseases

zhang

Yang

et al. 2016

Oncotarget

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Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.

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Section: Sex Chromosome Abnormalities In Psychiatric Diseasesmentioning

confidence: 99%

Sex chromosome abnormalities and psychiatric diseases

zhang

Yang

et al. 2016

Oncotarget

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“…As a matter of fact, in literature we find this syndrome often associated with low IQ level, cognitive impairment [16][17][18][19][20] delays in speech and language [21][22][23], poor writing skills [24] and learning disabilities [23,25] Attention-deficit Hyperactivity Disorder [26,27] social-emotional problems [23,28,29] and sometimes autistic behavior [23,28,[30][31][32][33].…”

Section: Xyy Syndromementioning

confidence: 99%

47, XYY Karyotype and Borderline Personality Disorder: An Italian Judicial Case and a Review of the Literature

Birkhoff¹

2015

J Child Adolesc Behav

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During the 1960s and the 1970s, some studies postulated that Jacobs' Syndrome can lead to aggressive and/or criminal behavior, but the statistical certainty was questioned. In the 1990s new discoveries in neuroscience and genetics brought new attention to a possible biological component of deviance. In this context forensic psychiatrists were required to express opinions about a young Italian man afflicted by 47,XYY karyotype (Jacobs' Syndrome) and Borderline Personality Disorder who had frequent violent behaviors against his relatives, being therefore accused of "abuse against family members or partners" (art. 572 Italian Penal Code). The Court disposed for an evaluation of his mental conditions, his imputability and his possible social dangerousness, analyzing the influences on behavior from both his mental and genetic conditions.

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