Acute pancreatitis associated to the use of valproic acid

Guevara-Campos, José; González-Guevara, Lucía; Vacaro-Bolívar, Ixora; Rojas, Juan Manuel

doi:10.1590/s0004-282x2009000300028

Cited by 14 publications

(4 citation statements)

References 17 publications

(17 reference statements)

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“…49 Some cases show rapid progression in bleeding from the initial symptoms until death; some are observed after the initial medication; and some appear after few years of medication. 50 The mortality rates of acute pancreatitis in children and adult patients are 15.4% and 21.4%, respectively. 12 A pharmacological research has recommended the maximum daily VPA dose of 2,500 mg, and the authors' patient was taking 1,500 mg of VPA a day.…”

Section: Discussionmentioning

confidence: 99%

A Rare Complication of Valproate-Induced Acute Pancreatitis in an Adult Patient with Bipolar Disorder: A Case Report

2023

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Background: Valproate-induced pancreatitis is an idiosyncratic reaction of the drug, commonly seen in the paediatric age group, between 1 week to 8 years of starting the drug. Case: The authors present a case report of a 61-year-old patient who presented with acute pancreatitis. All common causes were ruled out. The patient had a significant treatment history of taking valproate for bipolar disorder for 12 years. The patient was resuscitated with intravenous fluids and analgesics. Sodium valproate was stopped. The patient was monitored to detect early symptoms of systemic inflammatory response syndrome or any organ dysfunction or failure. The patient was sent to the ward after 4 days. The patient had a good outcome due to early diagnosis and resuscitation. Conclusion: Acute pancreatitis is a rare and potentially fatal complication in patients on valproate. After ruling out other common causes, a detailed medical and treatment history can lead to the diagnosis of this entity. Healthcare providers should be vigilant about the early signs and symptoms of pancreatitis, including acute abdomen, vomiting, and raised serum amylase and lipase.

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Section: Discussionmentioning

confidence: 99%

A Rare Complication of Valproate-Induced Acute Pancreatitis in an Adult Patient with Bipolar Disorder: A Case Report

2023

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“…20 Also, in all of the case reports of valproic acid–induced acute pancreatitis, 75% occurred in the pediatric population. 21 As valproic acid is the most widely used antiepileptic drug in children, 22 it is probably the most frequent cause of drug-induced pancreatitis 2 followed by different other antiepileptic drugs. The duration of treatment of epilepsy with either single-drug regimen or multiple drug regimens had no correlation with either serum amylase or lipase levels.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Subclinical Pancreatitis in Epileptic Children With Different Treatment Modalities

Mahrous

Hakeem

Aziz

et al. 2016

Child Neurology Open

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Acute pancreatitis differ in pediatrics and adults. Drug-induced pancreatitis is one of the common causes of pancreatitis in children. This case–control study aimed to assess subclinical pancreatitis in patients with epilepsy treated with different drug regimens. Eighty known patients with epilepsy were enrolled. Forty patients were treated with monotherapy (group I) and 40 were treated with multitherapy (group II) regimens. Twenty age- and sex-matched healthy children were enrolled as control (group III). Serum lipase and amylase were assayed in all included children. Significant differences were found between groups I and III and between groups II and III regarding serum amylase and lipase (P < .001 for all). Significant difference were found between groups I and II (P = .024) and between groups II and III (P = .01) regarding pancreatic duct and body diameters. Significant difference were found between patients with controlled and uncontrolled fits regarding serum amylase (P = .008). In conclusion, subclinical pancreatitis can complicate the treatment with different antiepileptic regimens.

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“…AST: Aspartat amino transferaz LDH: Laktat dehidrogenaz CRP: C-reaktif protein saptanan L-asparajinaz, valproik asit ve steroid gibi ilaçlar üst s›ralarda yer almaktad›r (11,12). Çocuklardaki akut pankreatitin daha çok ödematöz oldu¤u ve ölüm oran›n›n az oldu¤u bilinse de, valproik asite ba¤l› geliflen ve ölümcül seyreden akut hemorajik pankreatit bildirilmifltir (13).…”

Section: Tablo 3 Hastalar›n Baz› Biyokimyasal De¤erlerinin Ortalamalar›unclassified

Çocukluk çağı pankreatitleri: 20 vakanın klinik analizi

Çaltepe¹,

Kalaycı²,

Kirmemiş³

2011

tpa

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Ç Ço oc cu uk kl lu uk k ç ça a¤ ¤› › p pa an nk kr re ea at ti it tl le er ri i: : 2 20 0 v va ak ka an n› ›n n k kl li in ni ik k a an na al li iz zi i P Pa an nc cr re ea at ti it ti is s i in n c ch hi il ld dh ho oo od d: : C Cl li in ni ic ca al l a an na al ly ys si is s o of f 2 20 0 c ca as se es s G Gö ön nü ül l D Di in nl le er r Ç Ça al lt te ep pe e, , Ö Öz zl le em m K K› ›r rm me em mi ifl fl, , A Ay yh ha an n G Ga az zi i K Ka al la ay yc c› › Ö Öz zg gü ün n A Ar ra afl flt t› ›r rm ma a O Or ri ig gi in na al l A Ar rt ti ic cl le e Ö Öz ze et t Amaç: Çocukluk yafl grubunda pankreatitler çok s›k görülmemekte ve altta yatan risk etkenleri aç›s›ndan da eriflkinlerden farkl›l›k göstermektedir. Bu çal›flmada amac›m›z, pankreatit tan›s› ile izlenen hastalar›m›z›n belirgin özelliklerini ortaya koymakt›r.Gereç ve Yöntem: Son befl y›ll›k dönemde, klini¤imizde pankreatit tan›s› alan 20 hastan›n (19 akut, bir kronik pankreatit) hastalar›n klinik ve laboratuvar bulgular›, altta yatan risk etkenleri ve hastal›¤›n seyri geriye dönük olarak araflt›r›lm›flt›r. ‹statistik verileri, ortalama ±SD ve % ile ifade edilmifltir. Bulgular: Hastalar›n 14'ü k›z, 6's› erkekti. Yafl ortalamalar› 11,4±3,62 (2-18) y›ld›. Saptanabilen risk etmenlerinin bafll›calar›, sistemik hastal›klar (%15), ilaçlar (%15), biliyer hastal›klar (%15) ve travma (%10) fleklindeydi. Yinelemelerle seyreden bir kronik pankreatit olgusu kistik fibroz tan›s› alm›flt›. ‹ki hastada yineleyen ataklar izlendi (birinde kabakulak serolojik bulgusu saptand›, di¤erinde herhangi bir risk etkeni saptanamad›). Ondokuz akut pankreatitli hastaya ait 22 akut atak de¤erlendirildi. Serum amilaz ve lipaz düzeyleri s›ras›yla hastalar›n %81,8 ve %90,9'unda yüksekti. Psödokist (%10), venöz tromboz (%10) ve nekrotizan pankreatit (%5) en s›k görülen komplikasyonlard›. Akut atak s›ras›nda ve izlemde kaybedilen hasta olmad›. Ç›kar›mlar: Sistemik hastal›klar, ilaçlar, biliyer hastal›klar ve travma çocukluk ça¤› pankreatitlerinin en önemli risk etkenlerini oluflturmaktad›r. Çocuklarda ölüm düflük olmakla beraber, özellikle fliddetli olgular, psödokist ve venöz tromboz gibi geliflebilecek komplikasyonlar aç›s›ndan yak›n izlenmelidir. (Türk Ped Arfl 2011; 46: 49-54)Anahtar sözcükler: Çocukluk ça¤›, L-asparajinaz, nekrotizan pankreatit, pankreatit, psödokist, valproik asit, venöz tromboz S Su um mm ma ar ry y Aim: Pancreatitis rarely occurs in childhood and the underlying causes differ from adults. The aim of this study is to evaluate the documentation of characteristics of our cases diagnosed as pancreatitis. Material and Method:Of the 20 patients (19 acute, one chronic) who diagnosed as pancreatitis in our clinic during a five year period were analyzed retrospectively, considering clinical and laboratory findings, underlying risk factors and outcome of the illness. Data were analysed with SPSS 16.0 computer package programme. Results:Of the 20 patients 14 were female and 6 were male. The mean age was 11.4±3.62 (2-18) years. The most common risk factors were systemic disease...

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Acute pancreatitis associated to the use of valproic acid

Cited by 14 publications

References 17 publications

A Rare Complication of Valproate-Induced Acute Pancreatitis in an Adult Patient with Bipolar Disorder: A Case Report

A Rare Complication of Valproate-Induced Acute Pancreatitis in an Adult Patient with Bipolar Disorder: A Case Report

Assessment of Subclinical Pancreatitis in Epileptic Children With Different Treatment Modalities

Çocukluk çağı pankreatitleri: 20 vakanın klinik analizi

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