Color doppler evaluation of the influence of type of delivery, sex, postnatal age and time post feeding on full term healthy newborns cerebral blood flow

Abstract

-Objective: The purpose of this study was to evaluate with Color Doppler the influence of type of delivery, sex, postnatal age and time post feeding on full term healthy newborns cerebral blood flow. Method: 50 newborns were studied. The Doppler parameters, peak-systolic velocity, end-diastolic velocity, mean velocity, pulsatility index and resistance index, were measured in the anterior cerebral artery, middle cerebral artery, posterior cerebral artery, and basilar artery. The data were compared and analyzed by statistical tests. Informed consent was obtained from all parents, and the study was approved by institutional ethical committee and review board. Results: We observed not statistically significant differences on cerebral blood flow Doppler parameters in relation to type of delivery, sex, postnatal age and feeding in full term healthy newborns. Conclusion: We believe that the knowledge of these cerebral hemodynamic profile of newborns in the first days of life can contribute in an accurate interpretation of cranial Doppler abnormal findings when pathologic flow velocities are analyzed.KEY WORDS: color Doppler, ultrasonography, cerebral arteries, newborn, blood flow velocity, delivery, sex postnatal age, time post feeding. Doppler colorido na avaliação da influência do tipo de parto, sexo, idade pós-natal e tempo pós-mamada no fluxo sanguíneo cerebral em recém-nascidos a termo e saudáveis resumo -Objetivo: O objetivo deste estudo foi avaliar com Doppler colorido a influência do tipo de parto, sexo, idade pós-natal e tempo pós-mamada no fluxo sanguíneo cerebral de recém-nascidos a termo e saudáveis. Método: Foram estudados 50 recém-nascidos. A Dopplervelocimetria foi obtida nas artérias cerebral anterior, cerebral média, cerebral posterior e basilar. Os parâmetros foram comparados e analisados pelos testes estatísticos Esta pesquisa foi aprovada pela comissão ética e de pós-graduação das instituições e o consentimento informado dos pais foi obtido em todos os casos. Resultados: Não observamos diferenças estatísticamente significativas na Dopplervelocimetria do fluxo sanguíneo cerebral em relação ao tipo de parto, sexo, idade pós-natal e tempo pós-mamada dos recém-nascidos normais e saudáveis estudados. Conclusão: Acreditamos que o conhecimento deste perfil hemodinâmico do fluxo sanguíneo cerebral de recém-nascidos nos primeiros dias de vida possa contribuir para uma acurada interpretação dos achados do Doppler cerebral quando alterações patológicas de velocidade do fluxo sanguíneo forem analisadas.

Cerebral blood flow velocities and cerebrovascular resistance in normal‐term neonates in the first 72 hours

“…All results were in agreement with previous published studies . The average RI as determined in this study corresponds to those studies with similar post‐natal age and gestation (refer to Appendix for an overview of relevant studies) .…”

Is there any influence of breastfeeding on the cerebral blood flow? A review of 256 healthy newborns

“…The results of this original study with noninvasive cranial Doppler ultrasonography, including 256 healthy neonates to establish the influence of breastfeeding on the cerebral blood flow velocities, showed the occurrence, during breastfeeding, of an increase in MV and a decrease in the resis- tive index and pulsatility index as compared with values at rest, probably due to the increase in the cardiac output caused by the sucking effort, in agreement with other related studies (8,(26)(27)(28) .…”

“…The majority of studies involving Doppler ultrasonography in newborns and relating feeding and arterial blood flow velocities are concerned with the splanchnic haemodynamics adaptation to meal composition in normal full-term newborns (8,(22)(23)(24)(25) , the adaptation to the first feed (26)(27)(28) and the effect of enteral feeding on preterm newborns (29) .…”

Comparison of Umbilical Cord Milking and Delayed Cord Clamping on Cerebral Blood Flow in Term Neonates

“…The authors did not find any difference in CBF in relation to mode of delivery, sex, postnatal age and feeding in the present study. Aranha et al also demonstrated in their study that there is no significant difference in relation to above parameters in full term healthy babies [13]. However, Baenzinger et al reported that CBF in preterm neonates is substantially affected by sex, intrauterine growth and need of mechanical ventilation and has given possible explanation that in preterm neonates CBF seems to be dependent on the systemic blood pressure in the first 36h of life probably due to hormonal changes and differences in blood viscosity and cardiac output [14].…”

“…The mean of PI was 1.18 in either categories with (SD) of 0.26 for UCM group and 0.25 for DCC group respectively (p value 0.91). The peak systolic velocity (cm/s) and end diastolic velocity (cm/s) of blood flow in middle cerebral artery (MCA) for the UCM group was 34.94 (11.82) and 11.71 (SD 4.75) respectively while in the DCC group it was 37.24 (12.63) and 13.07 (4.78) (p value 0.23 and 0.07). The mean velocity (cm/ s) in MCA was found to be 18.96 (6.57) for the UCM group and 20.95 (7.23) for the DCC group (p value 0.06).…”