Cefaléia no lupus eritematoso sistêmico: prevalência e condições associadas

Bettero, Raphael Guimarães; Rahal, Mansur Youssef; Barboza, Joaquim S; Skare, Thelma L.

doi:10.1590/s0004-282x2007000700020

Cited by 8 publications

(13 citation statements)

References 10 publications

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“…22 Since this systematic review, nine studies have assessed headache in patients with SLE using control groups. [27][28][29][30][31][32][33][34][35] These studies are summarized in Table 1. Among those that reported data regarding all headaches, only two reported a higher prevalence of this symptom in patients with SLE compared to the control group.…”

Section: Primary Headachesmentioning

confidence: 99%

“…Among those that reported data regarding all headaches, only two reported a higher prevalence of this symptom in patients with SLE compared to the control group. 29,31 Although there is a similar prevalence to the general population, headache in patients with SLE tends to occur with a high monthly frequency. In approximately one-third of patients with headache, it is daily.…”

Section: Primary Headachesmentioning

confidence: 99%

“…7,35 The prevalence of migraine in patients with SLE ranged from 25% to 66.1%. [29][30][31] The association between migraine and SLE is controversial. [29][30][31][32][33][34] The prevalence of tension-type headache ranged from 26.9% to 60%.…”

Section: Primary Headachesmentioning

confidence: 99%

“…[29][30][31] The association between migraine and SLE is controversial. [29][30][31][32][33][34] The prevalence of tension-type headache ranged from 26.9% to 60%. [32][33][34] Only one study reported a higher prevalence of chronic tension-type headache in patients with SLE compared to the control group.…”

Section: Primary Headachesmentioning

confidence: 99%

“…29 Nevertheless, most of the controlled studies reported no association between headache or migraine and the presence of aPL. 27,31,[33][34][35][36]38,40,42 Furthermore, the association of headache or migraine with Raynaud's phenomenon was reported by some authors, [28][29][30] although most of the studies reported no such association. 27,31,[34][35][36]38,39 There are no clinical trials that assessed the acute or preventive treatment of primary headaches in patients with SLE.…”

Section: Primary Headachesmentioning

confidence: 99%

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Headache and systemic lupus erythematosus: A narrative review

Oliveira

Rocha-Filho

2023

Headache

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Objective To review the epidemiology, the differential diagnosis, and the clinical and laboratory factors associated with the care management of headaches in patients with systemic lupus erythematosus (SLE). Background SLE is a chronic autoimmune disease and in 12%–95% of patients, the nervous system is involved. Headache is a frequently reported, although nonspecific, symptom that may potentially represent serious underlying diagnoses. Primary headaches may also occur in these patients, thereby causing a negative and significant impact on their quality of life. Methods This is a narrative review. A literature review was conducted on the PubMed platform using the following terms: (1) headache and (2) lupus. All articles considered relevant were included. No limitations were imposed for the publication date. Results Headache is a frequent symptom in patients with SLE. Although its prevalence is similar to the general population, headaches nonetheless tend to have a greater negative impact on these patients. Patients with SLE are more likely to experience headache due to vascular diseases such as cerebral venous sinus thrombosis, stroke, reversible cerebral vasoconstriction syndrome, posterior reversible encephalopathy syndrome, and vasculitis. Aseptic meningitis, neuroinfections, intracranial neoplasms, and intracranial hypertension or hypotension may also be a cause of headache in these patients. Although used in disease activity scores, the concept of lupus headache is controversial. Conclusions Headache is a frequent symptom in patients with SLE. An appropriate approach enables the potentially serious conditions, which are the causes of secondary headaches, to be recognized and treated, together with an appropriate diagnosis and treatment of primary headaches.

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Section: Primary Headachesmentioning

confidence: 99%

Section: Primary Headachesmentioning

confidence: 99%

Section: Primary Headachesmentioning

confidence: 99%

Section: Primary Headachesmentioning

confidence: 99%

Section: Primary Headachesmentioning

confidence: 99%

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Headache and systemic lupus erythematosus: A narrative review

Oliveira

Rocha-Filho

2023

Headache

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Causal association between systemic lupus erythematosus and the risk of migraine: A Mendelian randomization study

Ren,

Yu,

Xiao

et al. 2024

Brain and Behavior

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BackgroundNumerous studies have found that patients with systemic lupus erythematosus (SLE) often have comorbid headache, especially migraine. However, the causal relationship between genetically determined SLE and migraine risk remains unclear. Therefore, we conducted a Mendelian randomization (MR) study to explore this causal association.MethodsGenome‐wide association studies (GWAS) provided the instrumental variables. We selected summary data from GWAS of SLE as exposure (5201 SLE patients and 9066 controls). Both outcome GWAS data were from the Finnish Gene GWAS, including migraine with aura, migraine with aura and triptan purchases, and migraine without aura. The main MR approach was inverse‐variance weighted. Pleiotropy and heterogeneity were detected using the MR pleiotropy residual sum and outlier, MR‐Egger intercept test, leave‐one‐out analysis, and Cochran's Q test.ResultsThere was a significant association between genetically predicted SLE susceptibility and increased risk of migraine with aura [odds ratio (OR) = 1.05, 95% confidence interval (CI) = 1.02–1.08, p = .001]. The result was consistent when the outcome was migraine with aura and triptan purchases [OR = 1.05, 95% CI = 1.02–1.08, p = .001]. However, we found no association between SLE and migraine without aura. Our MR study showed no pleiotropy or heterogeneity.ConclusionsOur study indicates that genetic susceptibility to SLE increases the incidence of migraine with aura but not migraine without aura. It is necessary for the routine evaluation and early recognition of migraine in patients with SLE in clinical settings.

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