Effects of hypertonic saline solution and mannitol in acute intracranial hypertension in rabbits

Abstract

Objectives: Review the current, extensive, literature on this topic in order to analyze whether the radiographic criteria mentioned in several studies (kyphosis, wegding of the vertebra, spinal canal compression, and ligament lesion) can be used to indicate instability of the burst fracture and the need for surgical treatment in patients without neurological deficit. Methods: We performed online searches of the Medline, LILACS, and Cochrane Library. Studies that were classified as being of interest were those that met the following inclusion criteria: adult patients; Dennis burst-type or Magerl A3 fracture affecting the thoracolumbar spinal segments; single level, non-pathological or osteoporotic fracture; and normal neurological examination. Results: The final selection included 80 studies that discuss conservative or surgical treatment. Iden-* Efeitos de solução salina hipertônica e manitol em coelhos com hipertensão intracraniana aguda (Resumo).