Temporal pole signal abnormality on MR imaging in temporal lobe epilepsy with hippocampal sclerosis: a fluid-attenuated inversion-recovery study

Carrete, Henrique; Abdala, Nitamar; Lin, Kátia; Caboclo, Luís Otávio Sales Ferreira; Centeno, Ricardo Silva; Sakamoto, Américo Ceiki; Szjenfeld, Jacob; Nogueira, Roberto Gomes; Yacubian, Elza Márcia Targas

doi:10.1590/s0004-282x2007000400001

Cited by 11 publications

(3 citation statements)

References 19 publications

(24 reference statements)

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“…In our study, the left hippocampus was more involved than the right side, and the head of the hippocampus was more involved than the body and tail. The results were similar in the previous studies [ 30 - 32 ].…”

Section: The Sensitivity Of Mri T2 Relaxometry and Petsupporting

confidence: 92%

Comparison of T2 relaxometry and PET CT in the evaluation of patients with mesial temporal lobe epilepsy using video EEG as the reference standard

Varatharajaperumal¹,

Arkar²,

Arunachalam³

et al. 2021

pjr

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Section: The Sensitivity Of Mri T2 Relaxometry and Petsupporting

confidence: 92%

Comparison of T2 relaxometry and PET CT in the evaluation of patients with mesial temporal lobe epilepsy using video EEG as the reference standard

Varatharajaperumal¹,

Arkar²,

Arunachalam³

et al. 2021

pjr

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“…The interobserver correlation was high on myelin maps, which showed the reliability of the SyMRI in practical life. Loss of the GM-WM differentiation, decreased T1, and increased T2 signal intensity in the ipsilateral anterior temporal lobe in patients with TLE ranging between 58 and 75% in studies vary depending on clinical profile of the patients [8,9]. Histopathological investigations showed a decreased amount of myelinated axons in HS patients with temporal pole signal abnormalities on MRI when compared to HS patients without signal abnormalities [6,22] compatible with experimental studies [23].…”

Section: Discussionsupporting

confidence: 62%

“…Atrophy of the ipsilateral mammillary body, fornix, and thalamus can also be seen [7]. Ipsilateral temporal pole signal abnormality in HS is another frequently associated finding on MRI [8,9].…”

Section: Introductionmentioning

confidence: 99%

Reduced myelin in patients with isolated hippocampal sclerosis as assessed by SyMRI

et al. 2021

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Purpose Synthetic MRI (SyMRI) enables to quantify brain tissue and morphometry. We aimed to investigate the WM and myelin alterations in patients with unilateral hippocampal sclerosis (HS) with SyMRI. Methods Adult patients with isolated unilateral HS and age-matched control subjects (CSs) were included in this study. The SyMRI sequence QRAPMASTER in the coronal plane perpendicular to the hippocampi was obtained from the whole brain. Automatic segmentation of the whole brain was processed by SyMRI Diagnostic software (Version 11.2). Two neuroradiologists also performed quantitative analyses independently from symmetrical 14 ROIs placed in temporal and extratemporal WM, hippocampi, and amygdalae in both hemispheres. Results Sixteen patients (F/M = 6/10, mean age = 32.5 ± 11.3 years; right/left HS: 8/8) and 10 CSs (F/M = 5/5, mean age = 30.7 ± 7 years) were included. Left HS patients had significantly lower myelin and WM volumes than CSs ( p < .05). Myelin was reduced significantly in the ipsilateral temporal lobe of patients than CSs, greater in left HS ( p < .05). Histopathological examination including luxol fast blue stain also revealed myelin pallor in all of 6 patients who were operated. Ipsilateral temporal pole and sub-insular WM had significantly reduced myelin than the corresponding contralateral regions in patients ( p < .05). No significant difference was found in WM values. GM values were significantly lower in hippocampi in patients than CSs ( p < .05). Conclusion SyMRI revealed myelin reduction in the ipsilateral temporal lobe and sub-insular WM of patients with HS. Whether this finding correlates with electrophysiological features and SyMRI could serve as lateralization of temporal lobe epilepsy need to be investigated. Supplementary Information The online version contains supplementary material available at 10.1007/s00234-021-02824-6.

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Temporal Lobe Resections

Zentner¹

2020

Surgical Treatment of Epilepsies

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Temporal pole signal abnormality on MR imaging in temporal lobe epilepsy with hippocampal sclerosis: a fluid-attenuated inversion-recovery study

Abstract: Our FLAIR study show temporal pole signal abnormality in 3/4 of patients with HS, mainly seen on the anteromedial region, with a larger prevalence when the left hippocampus was involved.

Cited by 11 publications

References 19 publications

Comparison of T2 relaxometry and PET CT in the evaluation of patients with mesial temporal lobe epilepsy using video EEG as the reference standard

Comparison of T2 relaxometry and PET CT in the evaluation of patients with mesial temporal lobe epilepsy using video EEG as the reference standard

Reduced myelin in patients with isolated hippocampal sclerosis as assessed by SyMRI

Temporal Lobe Resections

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